Registration Dossier

Ecotoxicological information

Toxicity to microorganisms

Currently viewing:

Administrative data

Endpoint:
toxicity to microorganisms
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non-Guideline, non-GLP, limitations in reporting but otherwise adequate for assessment.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1990
Report Date:
1990

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Oxygen consumption according to ROBRA
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): MBDA

Sampling and analysis

Analytical monitoring:
no

Test solutions

Vehicle:
yes
Details on test solutions:
Vehicle: Cremophor RH 40 (100 mg/L). An emulsion was reported to be formed.

Test organisms

Test organisms (species):
other: not specified

Study design

Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h

Test conditions

Test temperature:
21.8 and 22.2 °C
pH:
4.81-7.51
Nominal and measured concentrations:
- Nominal concentrations: 0 (control), 156.25, 312.5, 625, 1250, 2500, 5000 and 10000 mg/L
Reference substance (positive control):
no

Results and discussion

Effect concentrationsopen allclose all
Duration:
48 h
Dose descriptor:
EC10
Effect conc.:
372 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
other: oxygen consumption
Remarks on result:
other: non-neutralised test solutions
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
2 639 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
other: oxygen consumption
Remarks on result:
other: non-neutralised test solutions

Any other information on results incl. tables

PH

Concentration (mg/L)

Oxygen use (mg/L*min)

1

2

MW

MW%

7.51

BLW (Cremophor)

2.25

2.1

2.175

100

7.51

BLW (Cremophor)

2.15

2.2

4.81

10000

0.15

0.15

0.15

6.9

6.70

5000

0.65

0.65

0.65

29.9

7.19

2500

1.15

1.1

1.125

51.7

7.41

1250

1.45

1.55

1.5

69.0

7.48

625

1.6

1.65

1.625

74.7

6.95

1000 (neutral)

0.15

0.1

0.125

5.7

7.44

BLW (Cremophor)

2.15

2.05

2.05

100

7.44

BLW (Cremophor)

2.1

1.9

7.50

312.5

2.05

1.85

1.95

95.1

7.51

156.25

2.05

2.1

2.075

101.2

Applicant's summary and conclusion