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Diss Factsheets
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EC number: 937-955-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The reference does not contain complete study data. Furthermore, the test was conducted in accordance with methodology that is no longer considered to be acceptable or appropriate.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Reaction mass of 2-Ethylhexyl N-(5-isocyanato-2-methylphenyl)carbamate and 2-Ethylhexyl N-(3-isocyanato-4-methylphenyl)carbamate and N,N'-(4-Methyl-1,3-phenylene)bis(carbamic acid) C,C'-bis(2-ethylhexyl) ester
- EC Number:
- 937-955-6
- Molecular formula:
- components with the molecular formulae C25H42N2O4 and C17H24N2O3
- IUPAC Name:
- Reaction mass of 2-Ethylhexyl N-(5-isocyanato-2-methylphenyl)carbamate and 2-Ethylhexyl N-(3-isocyanato-4-methylphenyl)carbamate and N,N'-(4-Methyl-1,3-phenylene)bis(carbamic acid) C,C'-bis(2-ethylhexyl) ester
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS:
- Weight at study initiation: 206 - 240 g
- Diet (e.g. ad libitum):Appropriate Wayne diet, ad libitum.
- Water (e.g. ad libitum): ad libitum.
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- Two procedures were followed.
Static
Substantially saturated vapour was generated within a 120 litre Plexiglass chamber at 25.3 °C by magnetically stirring 200 grams of sample within a 250 cm surface area bowl and allowing the vapour to evolve for 16 hours prior to insertion of the rats. Six female Wistar rats were inserted into the exposure chamber following the 16 hour vapour generation period and inhaled the resultant vapour for an 8 hour period. Animals are added via a drawer-type self-sealing cage.
Alternate
Six female Wistar rats were inserted simultaneously with 200 grams of sample into a 120 litre exposure chamber at 25.7 °C and inhaled the resultant vapour for an 8 hour period.
The static procedure represents the maximum attainable vapour hazard at circa 25 °C, whereas the alternate is more representative of the worst conditions resulting from roller or brush application in a non-ventilated room. - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 8 h
- No. of animals per sex per dose:
- 6 animals were exposed in both scenarios.
- Control animals:
- no
- Details on study design:
- Signs of distress during the exposure period were noted.
in addition, bodyweight changes were observed for 14 days following exposure. At the end of the observation period, all animals wee necropsied.
Results and discussion
- Mortality:
- No mortality was observed.
- Clinical signs:
- other: During the static exposure, signs and symptoms seen included: coordination loss; breathing irregularities; eye irritation and clear exudate; anaesthesia. During the alternate exposure, signs and symptoms seen included: coordination loss; breathing irregul
- Body weight:
- Weight gains recorded throughout the 14 day observation period were considered normal for rats of this age and sex.
- Gross pathology:
- Static method: lung congestion seen in 2/6; liver dark and mottled seen in 1/6; endemic hydronephrosis seen in 1/6; nothing remarkable seen in 3/6.
Alternate method: lung congestion seen in 3/6; liver dark and mottled seen in 1/6; spleen dark and enlarged seen in 1/6; endemic hydronephrosis seen in 2/6; nothing remarkable seen in 2/6.
Applicant's summary and conclusion
- Conclusions:
- Little, if any, toxic hazard other than its sensitising potential is anticipated from the infrequent inhalation of substantially saturated vapour generated at room temperature.
- Executive summary:
The inhalation toxicity was investigated in rats. 12 female Wistar rats were exposed in two scenarios.
Static
Substantially saturated vapour was generated within a 120 litre Plexiglass chamber and was allowed to evolve for 16 hours prior to insertion of the rats. Six female Wistar rats were inserted into the exposure chamber following the 16 hour vapour generation period and inhaled the resultant vapour for an 8 hour period. Animals are added via a drawer-type self-sealing cage.
Alternate
Six female Wistar rats were inserted simultaneously with 200 grams of sample into a 120 litre exposure chamber and inhaled the resultant vapour for an 8 hour period.
Clinical signs observed during the exposure included coordination loss, breathing irregularities, eye irritation and anaesthesia.
No mortality occurred.
Little, if any, toxic hazard other than its sensitising potential is anticipated from the infrequent inhalation of substantially saturated vapour generated at room temperature.
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