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EC number: 235-730-0 | CAS number: 12627-14-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
LC50 (96 h): 260 - 310 mg/L (Onchorhynchus mykiss), RA sodium silicate
LC50 (96 h): 1108 mg/L (Brachydanio rerio), RA sodium silicate
NOEC (96 h, Mortality): 348 mg/L (Brachydanio rerio), RA sodium silicate
LC50 (96 h): >100 mg/L (Poecilia reticulata, limit test), lithium silicate solution; equivalent to 27.5 mg active matter/L
However, for the purpose of risk assessment and as explained in the section on the calculation of Predicted No Effect Concentrations, the PNEC is derived from the ubiquitous SiO2 background concentration in freshwater in Europe, which is 7.5 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 260 mg/L
Additional information
Two studies conducted with a related substance (sodium silicate) were selected as key studies. A semi-static study with Brachydanio rerio by Adema (1988), following OECD guideline 203, was performed under GLP for a sodium silicate solution (MR 3.46, 34.8 wt %). The 96 h LC50 was determined to be 1108 mg active matter/L. The NOEC values for mortality and swimming behaviour were 348 and 1114 mg active matter/L, respectively. The pH varied depending on the test substance concentration from 7.9 to 10.3.
In another non-GLP study, Maruyama et al. (1989) examined the toxicity of a neutralised sodium silicate solution (MR 3.1, concentration not indicated) to rainbow trout (Oncorhynchus mykiss). In four replicates the 96 h LC50 varied from 260 mg/L (pH 6.8 - 7.5) to 310 mg/L (pH 7.2 - 8.0). Necrosis of gill filaments as a result of the formation of colloidal silica was observed. However, this is considered a physical rather than toxic effect.
One non-GLP study is available reporting on the short-term toxicity to fish of silicic acid, lithium salt (aqueous solution, MR 4.05, solid content 27.5%), conducted according to OECD Guideline 203 as a limit test (Häner 1998). This study resulted in a 96 h LC50 value for Poecilia reticulata of > 100 mg/L nominal (test material), equivalent to 27.5 mg active matter/L. As one fish died during the test, this would have implied the conduct of a full study. However, the results are reported here as supporting study as they fit into the toxicity profile established by data from related analogue substances.
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