Registration Dossier
Registration Dossier
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EC number: 230-745-9 | CAS number: 7300-34-7
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The substance is with high probability acutely not harmful for aquatic invertebrates.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 218 mg/L
Additional information
For the assessment of the acute toxicity of DODA (CAS 7300-34-7) to aquatic invertebrates experimental data are not available. Therefore, in order to assess the ecotoxicity potential of the substance on the aquatic invertebrates a read-across approach was performed. The read-across approach consists of a short-term experimental study with TDDA (CAS 4246-51-9) to Daphnia magna. A non-GLP study was conducted with the test item in accordance with EU Method C.2 (Acute Toxicity for Daphnia) to determine the ability of the test substance to produce toxic effects and determine the EC50. In this static study Daphnia magna was used as a test organism.
The test solutions without pH-adjustment showed initial pH values between 8.62 and 10.25. However, the acceptable pH range for aquatic invertebrates is given in the OECD TG 202 as pH 6 to 9. This pH range is only kept in the three lowest test concentrations (≤ 9.65 mg/L), while the other test solutions showed initial pH values above 9.26. After 48 hours, the pH shifted to acceptable levels in all treatments. While only 10% mortality was observed in the highest test treatment after pH-adjustment after 24 h, 95% fish died in the highest test treatment without pH-adjustment. Therefore, it can be concluded that the ecotoxicity effect of the substance was influenced by the alkalinity in the test treatments. After 48 h, the EC50 was determined to be 218.2 mg/L without pH adjustment of the test solutions (BASF AG 1989, report no. 1/0505/2/89-0505/89).
The concentrations were not analytically verified. However, the test concentrations are assumed to be stable over the exposure period based on a sufficient water solubility, a low Henry's Law constant (7.86E-08 Pa*m³/mol, calc., see IUCLID Ch. 5.4.2) and a low adsorption potential (log Kow = -2.5, meas., see IUCLID Ch.4.7; log Koc = 1.48, calc., see IUCLID Ch. 5.4.1).
Therefore, it can be concluded that based on the available read-across experimental data from the structurally similar substance (CAS 4246-51-9), it can be concluded that the substance is with high probability acutely not harmful for aquatic invertebrates.
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