Registration Dossier
Registration Dossier
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EC number: 226-540-9 | CAS number: 5421-46-5
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- The systemic actions of thioglycerol with special reference to goitrogenic activity
- Author:
- Kensler, C.J. and Elsner, R.W.
- Year:
- 1 949
- Bibliographic source:
- J. Pharmacol. Exp. Therap., 97, 349-357.
Materials and methods
- Principles of method if other than guideline:
- other: systemic effects after i.p. application in mice
- GLP compliance:
- no
Test material
- Reference substance name:
- Ammonium mercaptoacetate
- EC Number:
- 226-540-9
- EC Name:
- Ammonium mercaptoacetate
- Cas Number:
- 5421-46-5
- Molecular formula:
- C2H4O2S.H3N
- IUPAC Name:
- ammonium 2-sulfanylacetate
- Details on test material:
- - Name of test material (as cited in study report): Thioglycolic acid administered as ammonium salt
- Concentration: 10.7%
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Doses:
- no data
- No. of animals per sex per dose:
- 27 (total number)
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 200 mg/kg bw
Any other information on results incl. tables
TGA poisoning is characterized by a prolonged period of depression. Animals given fatal doses usually died between 12 and 36 hours after injection.
Applicant's summary and conclusion
- Conclusions:
- The i.p. LD50 of ATG in mice is 200 mg/kg bw.
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