2-Propanone, 2,2',2''-[O,O',O''-(ethylsilylidyne)trioxime]

Genetic toxicity: in vivo

Administrative data

Endpoint:

in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus

Remarks:

Type of genotoxicity: chromosome aberration

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The analogue substance Wasox-VMAC2, which shares the same functional groups with EAC, also has comparable values for the relevant molecular properties and therefore, both are expected to be toxicologically equivalent for the genetic toxicity

Cross-reference

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

other: Read-across

Title:

Unnamed

Year:

2012

Materials and methods

Principles of method if other than guideline:

Read-across approach from experimental data (OECD Guideline 474, GLP study) with analogue substance Wasox-VMAC2.

GLP compliance:

no

Type of assay:

micronucleus assay

Test material

Test material information

Constituent 1

Reference substance name:

acetone O,O'-[methoxy(vinyl)silanediyl]oxime; acetone O,O',O''-(vinylsilanetriyl)oxime and acetone O-[dimethoxy(vinyl)silyl]oxime

IUPAC Name:

acetone O,O'-[methoxy(vinyl)silanediyl]oxime; acetone O,O',O''-(vinylsilanetriyl)oxime and acetone O-[dimethoxy(vinyl)silyl]oxime

Constituent 2

Reference substance name:

797751-44-1

Cas Number:

797751-44-1

IUPAC Name:

797751-44-1

Constituent 3

Reference substance name:

A mixture of: propan-2-one-O,O'(methoxyvinylsilandiyl)dioxime; propan-2-one-O-(dimethoxyvinylsilyl)oxime; propan-2-one-O,O',O''-(vinylsilantriyl)trioxime

EC Number:

458-680-3

EC Name:

A mixture of: propan-2-one-O,O'(methoxyvinylsilandiyl)dioxime; propan-2-one-O-(dimethoxyvinylsilyl)oxime; propan-2-one-O,O',O''-(vinylsilantriyl)trioxime

IUPAC Name:

458-680-3

Details on test material:

- Name of test material (as cited in study report): Wasox-VMAC2
- Molecular formula (if other than submission substance): Not applicable, multiconstituent substance
- Molecular weight (if other than submission substance): 231.627
- Smiles notation (if other than submission substance): Not applicable, multiconstituent substance
- InChl (if other than submission substance): Not applicable, multiconstituent substance
- Structural formula attached as image file (if other than submission substance): see Fig.

Results and discussion

Test results

Sex:

male/female

Genotoxicity:

negative

Remarks:

(at estimated doses of 799.26, 1198.90 and 1598.53 mg/kg)

Toxicity:

no effects

Remarks:

(at estimated doses of 1598.53 mg/kg)

Vehicle controls validity:

valid

Positive controls validity:

valid

Additional information on results:

Based on the experimental data on the analogue substance Wasox-VMAC2 which did not produce relevant increases of the number of micronuclei in polychromatic erythrocytes in mice of either sex at doses of 1000, 1500 and 2000 mg/kg bw and sampling times of 24 and 48 h, the read-across approach was applied and EAC3 was also considered not to produce micronuclei increases in polychromatic erythrocytes under test conditions.

Any other information on results incl. tables

See "Data Matrix" and "Reporting Format" attached.

Applicant's summary and conclusion

Conclusions:

Interpretation of results (migrated information): negative
Based on read-across approach from experimental results on analogue Wasox-VMAC2 (OECD Guideline 474, GLP study, test item EAC3 was considered not to produce relevant increase of the number of micronuclei in polychromatic erythrocytes under test conditions.

Executive summary:

Based on the experimental data (test method according to OECD Guideline 474 and GLP) on the analogue substance Wasox-VMAC2 which did not produce relevant increases of the number of micronuclei in polychromatic erythrocytes in mice of either sex at doses of 1000, 1500 and 2000 mg/kg bw and sampling times of 24 and 48 h, the read-across approach was applied and EAC3 was also considered not to produce micronuclei increases in polychromatic erythrocytes under test conditions.