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EC number: 412-280-5 | CAS number: 2511-00-4 POIRENATE
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 13 to 17 January 1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: According to the OECD Guideline 203 and it is GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Ethyl 2-cyclohexylpropionate
- EC Number:
- 412-280-5
- EC Name:
- Ethyl 2-cyclohexylpropionate
- Cas Number:
- 2511-00-4
- Molecular formula:
- C11H20O2
- IUPAC Name:
- ethyl 2-cyclohexylpropanoate
- Details on test material:
- - Physical state: clear liquid
- Stability under test conditions: ensured by daily renewal of test media and verified by chemical analysis. Water samples were taken from the control and each test concentration at 0 and 72 hours (fresh media) and at 24 and 96 hours (expired media).
- Storage condition of test material: in darkness at 4ºC
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- TEST ORGANISM
- Common name: Rainbow trout (Oncorhynchus mykiss)
- Source: Westacre Trout Farm, Westacre, Norfolk, U.K
- Length at study initiation (length definition, mean, range and SD): 5.5cm
- Weight at study initiation (mean and range, SD): 2.78g
ACCLIMATION
- Acclimation period: 8 days
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 150-200 mg/l CaCO3
- Test temperature:
- 14ºC
- pH:
- 7.1
- Dissolved oxygen:
- 10.1±0.1ºC
- Nominal and measured concentrations:
- Nominal concentrations mg/L: control, 10, 18, 32, 56, 100
Measured concentrations mg/L: control, 6.2, 12, 26, 42, 84 - Details on test conditions:
- TEST SYSTEM
- Test vessel: glass aquaria holding 40 litres of test media
Experimental design: 5 test concentrations plus 1 control and 10 animals per test concentration.
Method of initiation: fish placed in prepared test media
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 3 h
- Dose descriptor:
- LC50
- Effect conc.:
- 16 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 6 h
- Dose descriptor:
- LC50
- Effect conc.:
- 18 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- 12 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 12 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 72 h
- Dose descriptor:
- LC50
- Effect conc.:
- 9.9 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 8.6 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
Any other information on results incl. tables
- Sublethal observations / clinical signs:
Table 1
Cumulative mortality data for rainbow trout exposed for 96 hours to the test substance
Nominal concentration mg/l Measured concentration mg/l Cumulative mortality (initial population: 10) 3h 6h 24h 48h 72h 96h Control Control 0 0 0 0 0 0 10 6,2 0 0 0 0 0 0 18 12 0 0 6 6 9 10 32 26 9 10 10 10 10 10 56 42 10 10 10 10 10 10 100 84 10 10 10 10 10 10
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The LC50 at 96 hours was 8.6 mg/L.
- Executive summary:
The test substance was performed to obtain the acute toxicity to the rainbow trout. The test was under semi-static conditions and according to the PECD Guideline 203. The LC50 was 8.6 mg/L during 96 hours. The highest test concentration resulting in 0% motality was 6.2 mg/l and the lowest test concentration resulting in 100% moratility was 12 mg/l. The no observed effect level was 6.2 mg/l.
All results are based on mean measured concentrations. Values obtained ranged from 80 to 94% of nominal (mean value 86%) at 0 and 72 h (fresh media) and fresh media) and from 37 to 79% of nominal (mean value 57%) at 24 and 96 hours (expisred media).
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