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EC number: 209-193-8 | CAS number: 558-30-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The LD50 values derived from the key-studies were: LD50 (oral, rat) 3890 mg/kg bw and LD50 (dermal, rat) >4000 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 3 890 mg/kg bw
Additional information
Acute toxicity: oral
The acute oral toxicity of
2,2-dimethyloxirane in the rat was examined in an in-house study
following the principles of OECD TG 401 (BASF AG, 1980). Sprague Dawley
rats were given a single oral dose of 2,2-dimethyloxirane (14.7, 21.5,
31.6, 46.4 and 50.0 % emulsion in aqueous 0.5 % carboxymethyl cellulose)
at 1470, 2150, 3160, 4640, 6810 mg/kg bw. Animals were then observed for
mortality and for clinical symptoms of toxicity for 14 days. All animals
were subjected to necropsy. The oral LD50 was estimated as 3890 mg/kg
bw. This acute oral study is classified as acceptable.
Acute toxicity: inhalation
In an in-house acute inhalation toxicity study (BASF AG, 1980; inhalation risk test), Sprague Dawley rats were exposed to a saturated vapour-air mixture of 2,2-dimethyloxirane at 20° C for 3, 10 or 25 minutes and subsequently observed for mortality and for clinical symptoms of toxicity for 14 days. Due to the high vapour pressure extreme concentrations of approximately 133394, 225072 and 279998 ppm (corresponding to approximately 400, 674 and 839 mg/L) were achieved at 3, 10 and 25 min, respectively. All animals were subjected to necropsy. With reference to the exposure time, after 3 min 1/12, after 10 min 4/6, and after 25 min 4/6 rats died, showing as symptoms escape attempts, eyelid closure, salivation, intermittent respiration, gasping, discharge (eyes, nose), ruffy fur, slight erythema (ears, extremities) and unsteady gait. Gross pathology revealed right-sided acute dilatation of the heart. Surviving animals were without findings in gross necropsy. As the concentrations of the test substance exceeded by far the regulatory threshold concentration for vapours of 20 mg/L/4hr, the study does not allow to conclude on classification and labelling.
Acute toxicity: dermal
The acute dermal toxicity of 2,2-dimethyloxirane was examined in an in-house study following the principles of OECD TG 402 (BASF AG, 1980). Sprague Dawley rats were dermally exposed to unaltered 2,2-dimethyloxirane at dosages of 2000 and 4000 mg/kg bw. Animals were then observed for mortality and for clinical symptoms of toxicity for 14 days. All animals were subjected to necropsy. The oral LD50 was estimated > 4000 mg/kg bw. This acute dermal study is classified as acceptable.
Justification for classification or non-classification
Based on the results of the oral and dermal acute toxicity studies, no classification of 2,2-dimethyloxirane is needed according to Regulation 1272/2008/EC.
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