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EC number: 220-822-5 | CAS number: 2909-38-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- repeated dose toxicity: inhalation
- Remarks:
- other: 5 days repeated dose inhalation toxicity in 1 rabbit, 1 guinea pig, 2 rats and 4 mice
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No OECD Guideline or GLP defined. Insufficient data documentation, insufficient number of test animals used.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 960
- Report date:
- 1960
Materials and methods
- Principles of method if other than guideline:
- 4 ccm of a 20% dilution of the test substance in Methylenchloride were sprayed in a 400 l room, in which 1 rabbit, 1 guinea pig , 2 rats and 4 mice were tested. After 1 hour the same amount of test substance was sprayed again. After 2 hours the animals were taken out of the testing room. This test was repeated on 5 consecutive days.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- 3-chlorophenyl isocyanate
- EC Number:
- 220-822-5
- EC Name:
- 3-chlorophenyl isocyanate
- Cas Number:
- 2909-38-8
- Molecular formula:
- C7H4ClNO
- IUPAC Name:
- 1-chloro-3-isocyanatobenzene
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- other: rabbit, guinea pig, rats, mice
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: Methylenchloride
- Remarks on MMAD:
- MMAD / GSD: no data
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 5 days
- Frequency of treatment:
- twice daily (4 ccm of a 20% dilution of the test substance in Methylenchloride were sprayed in a 400 l room, in which 1 rabbit, 1 guinea pig , 2 rats and 4 mice were tested. After 1 hour the same amount of test substance was sprayed again. After 2 hours the animals were taken out of the testing room. This test was repeated on 5 consecutive days).
Doses / concentrations
- Remarks:
- Doses / Concentrations:
4 ccm
Basis:
no data
- No. of animals per sex per dose:
- 1 rabbit, 1 guinea pig , 2 rats and 4 mice
- Control animals:
- not specified
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
The animals reacted after the first spraying of test substance, a heavy mucosa irritation was observed together with difficulties in breathing. These syptoms intensified on day 2. On day 3 the guinea pig died, on day 4 one mouse died, an day 5 another mouse and one rat and 2 days after the end of the experiment the 2 other mice died. The rabbit died 7 days after the experiment and the 2 rats after 14 days.
Applicant's summary and conclusion
- Executive summary:
In a repeated dose inhalation study 4 ccm of a 20% dilution of the test substance in Methylenchloride were sprayed in a 400 l room, in which 1 rabbit, 1 guinea pig , 2 rats and 4 mice were tested. After 1 hour the same amount of test substance was sprayed again. After 2 hours the animals were taken out of the testing room. This test was repeated on 5 consecutive days.
The animals reacted after the first spraying of test substance, a heavy mucosa irritation was observed together with difficulties in breathing. These syptoms intensified on day 2. On day 3 the guinea pig died, on day 4 one mouse died, an day 5 another mouse and one rat and 2 days after the end of the experiment the 2 other mice died. The rabbit died 7 days after the experiment and the 2 rats after 14 days.
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