Registration Dossier
Registration Dossier
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EC number: 617-590-6 | CAS number: 846023-24-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 01-07 September 2009
- Reliability:
- 1 (reliable without restriction)
Data source
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: Organisation for Economic Co-operation and Development (OECD), OECD Guidelines for Testing of Chemicals, Draft Proposal for a New Guideline: In Vitro Skin Irritation: Reconstructed Human Epidermis (RhE) Test Method.
- Qualifier:
- according to guideline
- Guideline:
- other: European Community (EC). Commission regulation (EC) No. 761/2009, Part B: Methods for the Determination of Toxicity and other health effects, Guideline B.46 “In Vitro Skin Irritation: Reconstructed Human Epidermis Model Test ". Official Journal of the Eur
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-cyano-N-(2,4-dichloro-5-methoxyphenyl)acetamide
- EC Number:
- 617-590-6
- Cas Number:
- 846023-24-3
- Molecular formula:
- C10H8Cl2N2O2
- IUPAC Name:
- 2-cyano-N-(2,4-dichloro-5-methoxyphenyl)acetamide
- Details on test material:
- Molecular formula C10H8Cl2N2O2
Molecular weight 259.09
CAS Number 846023-24-3
Description Ivory flakes (determined at NOTOX)
Batch 18238505
Purity 97.3%
Test substance storage At room temperature in the dark
Stability under storage conditions Stable
Constituent 1
Test animals
- Species:
- other: Skin tissue (in vitro assay)
Test system
- Number of animals:
- n.a
Results and discussion
Any other information on results incl. tables
Skin irritation is expressed as the remaining cell viability after exposure to the test substance. The relative mean tissue viability obtained after 15 minutes treatment with WAY-186478 compared to the negative control tissues was 113%. Since the mean relative tissue viability for WAY-186478 was above 50% WAY-186478 is considered to be non-irritant.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Conclusions:
- Finally, it is concluded that this test is valid and that WAY-186478 is non-irritant in the in vitro
skin irritation test under the experimental conditions described in this report.
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