Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 407-950-9 | CAS number: 895-85-2 INTEROX-PMBP-70W; INTEROX-PMPB-70W
Endpoint summary
Administrative data
Description of key information
In a stability test (van Dam, 2014) at test conditions (pH 8, 20 °C) it was observed that bis(4-methylbenzoyl)peroxide is hydrolytically instable with a half-life of 2.3h. Therefore a full hydrolysis study was performed where the speed of hydrolysis at different environmentally relevant pHs and the formation of the main hydrolysis product p-toluic acid (CAS no. 99 -94 -5) was determined.
It is technically not feasible to obtain test concentrations of the parent substance close to the water solubility limit and to remove the non-dissolved fraction. With such fast hydrolysis at test conditions, the low water solubility of 43 µg/L and the technical difficulties it should be concluded that tests should be performed with hydrolysis products instead.
A full OECD SIDS dossier is available on p-toluic acid (OECD SIDS p-toluic acid, 2008). The data from the SIDS dossier have been used for
bis(4-methylbenzoyl)peroxide and are summarized here:
Eco-toxicity data of p-toluic acid are available in aquatic species from three trophic levels. GLP tests using a freshwater fish (OECD TG 203,Oryzias latipes), daphnids (OECD TG 202,Daphnia magna) and green alga (OECD TG 201,Pseudokirchneriella subcapitata) have been conducted.
The following acute toxicity values have been determined for aquatic species:
Oryzias latipes; 96h-LC50= 64 mg/L(measured concentration)
Daphnia magna; 48h-EC50= 42 mg/L (measured concentration)
Pseudokirchneriella subcapitata; 72h-ErC50= 74 mg/L (growth rate method, measured concentration)
The chronic toxicities on daphnids (OECD TG 211,Daphnia magna) and on algae (OECD TG 201,Pseudokirchneriella subcapitata) are available. The following chronic toxicity values have been determined for aquatic invertebrates and algae:
Daphnia magna; 21d-NOEC = 3.2 mg/L(measured concentration)
Pseudokirchneriella subcapitata; 72h-NOErC = 46 mg/L (growth rate method, measured concentration)
Several studies for all three trophic levels with bis(4-methylbenzoyl) peroxide were performed, but were all disregarded due to the low water solubility and the fast hydrolysis at test conditions as described above.
Toxicity of bis(4-methylbenzoyl)peroxide
to microorganisms was determined in a Robra test according to DIN 38412. An emulsifier was used. No effects were observed upto a concentration of 497 mg a.i./L and therefore 30min-NOEC is equal to or greater than 497 mg a.i./L and 30min-EC50 > 497 mg a.i./L.
The substance is therefore considered harmless to microorganisms.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
