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Diss Factsheets
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EC number: 205-359-9 | CAS number: 139-40-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Contains sufficient detail to suggest GLP-like characteristics even though no statement of certification is reported (reasonably thorough description of authors, dates, design, results, and interpretation).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The test substance was suspended with carboxymethyl-cellulose 2%. Before treatment the suspension was homogeneously dispersed with an Ultra-Turrax and during treatment it was kept stable with a magnetic stirrer.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Propazine
- EC Number:
- 205-359-9
- EC Name:
- Propazine
- Cas Number:
- 139-40-2
- Molecular formula:
- C9H16ClN5
- IUPAC Name:
- 6-chloro-N2,N4-bis(propan-2-yl)-1,3,5-triazine-2,4-diamine
- Details on test material:
- Product designation: propazine
Batch No. Lot. 368
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: bred rats of the Tif: RAIf (SPF) strain
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The animals were kept at a room temperature of 22 ± 10 °C, at a relative humidity of 55 ± 5 % anti on a 14 hours light cycle day. They received ad libitum rat food NAFAG, Gossau SG - and water. Prior, to treatment the animals were adapted to our laboratories for a minimum of 4 days and the initial body weight ranged from 160 to 180 grams
During the treatment and observation period the animals were housed ingroups of 5 in Macrolon cages (type 3)
Administration / exposure
- Route of administration:
- other: oral intubation
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- The substance was suspended with carboxymethyl - cellulose2 %. Before treatment the suspension was homogeneously dispersed with an Ultra - Turrax and during treatment it was kept stable with a magnetic stirrer.
- Doses:
- The following doeses have been given:
3170 mg/Kg
4640 mg/Kg
6000 mg/Kg
7750 mg/Kg
No higher doses were possible - No. of animals per sex per dose:
- Per each doses 5 male and 5 female have been treated.
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 7 700 mg/kg bw
- Mortality:
- Any mortality has been occurred within the 14 days of treatment.
- Clinical signs:
- other: Within 2 hours after treatment the rats in dosage groups showed sedation, dyspnoea, exophthalmus, curved position and ruffled fur.The animals recovered within 9 to 10 days.
- Gross pathology:
- The animals were submitted to a necropsy at the end of the observation period.
No substance related gross organ changes were seen.
Any other information on results incl. tables
Rate of deaths:
Dose mg/Kg |
No. of animals |
Died within 1 hr. 2 hrs. 48 hrs. 7 days 14 days |
||||||||||
M |
F |
M |
F |
M |
F |
M |
F |
M |
F |
M |
F |
|
3170 |
5 |
5 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
4640 |
5 |
5 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
6000 |
5 |
5 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
7750 |
5 |
5 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
M = male
F = female
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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