6-amino-1,3-dimethyluracil

Melting point / freezing point

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2002-06-12 (experimental phase)

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Version / remarks:

adopted July 27, 1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Version / remarks:

EEC Directive 92/69, Part A, Methods for the determination of physico-chemical properties, A.1 "Melting/Freezing temperature", EEC Publication No. L383, December 1992.

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

thermal analysis

Remarks:

via Differential Scanning Calorimeter

Specific details on test material used for the study:

- Storage condition of test material: at room temperature (at about 20 °C)

Key result

Melting / freezing pt.:

299 °C

Atm. press.:

1 013 hPa

Decomposition:

no

Remarks on result:

other:

Remarks:

Mean of two runs. During these runs, the samples lost 24.3 % and 37.3 % of their mass, respectively. After the measurement both samples were colored brownish yellow and of a clear melt.

The melting point of 1,3-DIMETHYL-4-AMINOURACIL was determined to be 299.0 °C±0.5°C which is equal to 572.2 K ± 0.5 K.

Conclusions:

The melting point of 1,3-DIMETHYL-4-AMINOURACIL is 299.0 °C±0.5°C.

Executive summary:

The determination of the melting point / melting range of the test item was performed according to the EEC Directive 92/69, A.1 "Melting/Freezing temperature", December 1992 and to the OECD Guideline No. 102;" Melting point / melting range", adopted July 27, 1995, under GLP. Thermal analysis was performed using a DSC apparatus.

The DSC-curve of the preliminary test (heating rate of 20 K/min from 25 °C to 400 °C) shows that an endothermic heat effect, the melting, was observed at 304.7 °C. After the experiment, the sample had lost about 62 % of its mass and the color of the sample was brownish black and carbonized.

In order to determine the melting more precisely, further DSC-runs were recorded between 275 °C and 325 °C with a heating rate of 5 K/min. In the first main test run, the melting of 1,3-DIMETHYL-4-AMINOURACIL was determined at 299.4 °C. The melting of the test item during the second main test run was determined to be at 298.7 °C. During these runs, the samples lost 24.3 % and 37.3 % of their mass, respectively.

In conclusion, the melting point of 1,3-DIMETHYL-4-AMINOURACIL was determined to be 299.0 °C±0.5°C.

Reference 2

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP-guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

GLP compliance:

yes (incl. QA statement)

Type of method:

thermal analysis

Key result

Melting / freezing pt.:

296 °C

Atm. press.:

1 013 hPa

Decomposition:

no

Reference 3

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: peer reviewed database

Guideline:

other: no data

GLP compliance:

no

Key result

Melting / freezing pt.:

295 °C

Description of key information

Melting Point:

296°C at 1013 hPa (thermal analysis, OECD 102, GLP)

295°C (database entry)

299°C at 1013 hPa (thermal analysis, OECD 102, GLP)

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:

299 °C