Registration Dossier
Registration Dossier
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EC number: 213-607-2 | CAS number: 993-13-5
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No details on test method provided.
- GLP compliance:
- not specified
- Test organisms (species):
- other: bluegill sunfish (species not defined)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 12.38 mg/L
- Conclusions:
- The 96h LC50 of MPA to bluegill sunfish was reported to be 12.38 mg/L.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No data on test method provided.
- GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- other: fathead minnow (species not defined)
- Test type:
- not specified
- Water media type:
- not specified
- Total exposure duration:
- 96 h
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 10.617 mg/L
- Conclusions:
- The 96h LC50 of MPA to fathead minnow was reported to be 10.617 mg/L.
Referenceopen allclose all
Description of key information
A nominal 96h-LC50 of 934.1 mg/l could be determined with read across substance MPAAU.
A valid fish acute toxicity study according to OECD TG 203 was conducted with read across material MPAAU (Pupp 2012). The active substance caused no mortality to Fathead minnow (Pimephales promelas) after 96-hours exposure to a nominal concentration of 583 mg/L in a static test, and a nominal 96h-LC50 of 934.1 mg/l could be determined.
The two studies with bluegill sunfish and Fathead Minnows of Williams 1987 were conducted with the target substance itself.
However, the review article of Munro et al. (1999) is giving no further information than the mere result. But these data only are known from this single secondary literature source, it is furthermore not possible to verify the correctness of the data by a second independent data source. Because of this, further attempts were undertaken to retrieve the original study report from U.S. military web services (USCEHR, NTIS), but unfortunately without success.
With no further clarification on data reliability possible, this renders the reliability of the two acute fish toxicity studies of Williams (1987) as not assignable (Klimisch 4).
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 934.1 mg/L
Additional information
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