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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Qualifier:
no guideline followed
Principles of method if other than guideline:
no data
GLP compliance:
no
Test type:
other: no data
Species:
rat
Strain:
not specified
Sex:
male/female
Route of administration:
oral: unspecified
Vehicle:
not specified
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Preliminary study:
no data
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 2 710 mg/kg bw
Based on:
not specified
Remarks on result:
other: no data
Mortality:
no data
Clinical signs:
other: no data
Gross pathology:
no data
Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The LD50 of cycloate is 2710 mg/bw-kg (rat).
Executive summary:

The LD50 of cycloate is 2710  mg/bw-kg ( rat).

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
2 710 mg/kg bw
Quality of whole database:
reliable

Acute toxicity: via inhalation route

Link to relevant study records
Reference
Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: EPA pesticide database
Qualifier:
no guideline followed
Principles of method if other than guideline:
no data
GLP compliance:
no
Test type:
other: no data
Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
no data
Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Details on inhalation exposure:
no data
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
ca. 4 h
Concentrations:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
no data
Sex:
not specified
Dose descriptor:
LC50
Effect level:
ca. 4.7 mg/L air
Based on:
not specified
Exp. duration:
4 h
Mortality:
no data
Body weight:
no change
Gross pathology:
no data
Interpretation of results:
Category 4 based on GHS criteria
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Cycloate is classified as acut inhalation toxic chemical substance category 4 ( H332) .
Executive summary:

Cycloate is classified as acut inhalation toxic chemical substance category 4 ( H332) . LC 50 (4h) for rats = 4.7 mg/l

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LC50
Value:
4 700 mg/m³ air

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Qualifier:
no guideline followed
Principles of method if other than guideline:
no data
GLP compliance:
no
Test type:
other: no data
Species:
rabbit
Strain:
not specified
Sex:
not specified
Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
no data
Duration of exposure:
no data
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
no data
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 4 640 other: mg/kg
Based on:
not specified
Remarks on result:
other: no data
Mortality:
no data
Clinical signs:
other: no data
Gross pathology:
no data

no data

Interpretation of results:
GHS criteria not met
Conclusions:
Thy cycloate is classifed as not acute toxic (dermal). LD50 is more than 4640 mg/kg bw.
Executive summary:

Thy cycloate is classifed as not acute toxic (dermal). LD50 is more than 4640 mg/kg bw.

Endpoint conclusion
Endpoint conclusion:
no study available
Dose descriptor:
LD50
Value:
4 640 mg/kg bw
Quality of whole database:
more than 4640 mg/kg

Additional information

Justification for selection of acute toxicity – oral endpoint

reliable test

Justification for selection of acute toxicity – inhalation endpoint

reliable test

Justification for classification or non-classification

It is classified as acute toxicity category 4 inhalation H332.