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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Hydrolysis

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
hydrolysis
Type of information:
(Q)SAR
Remarks:
QSAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Remarks:
QSAR
Justification for type of information:
QSAR
Qualifier:
no guideline followed
Principles of method if other than guideline:
QSAR
GLP compliance:
no
Radiolabelling:
not specified
Details on test conditions:
no data
Transformation products:
yes
No.:
#1
No.:
#1
No.:
#1
No.:
#1
pH:
7
Temp.:
25 °C
DT50:
> 100 d
Type:
not specified
Details on results:
See it in the attachement.
Validity criteria fulfilled:
not specified
Conclusions:
Prediction: HYDROWIN identified for the target Cycloate the chemical class “Thiocarbamate”.
In more detail, the class Thiocarbamate is identified when the target matches the following formula: -C-S-C(=O)-N-C. For the target, hydrolysis rate constatnt was not predicted, as it is
assumed, in the estimation model, that the common thiocarbamate function hydrolyzes very slow at environmental pHs with half-lives greater than 100 days.
Executive summary:

Prediction:  HYDROWIN identified for the target Cycloate the chemical class “Thiocarbamate”.

In more detail, the class Thiocarbamate is identified when the target matches the following formula: -C-S-C(=O)-N-C. For the target, hydrolysis rate constatnt was not predicted, as it is assumed, in the estimation model, that the common thiocarbamate function hydrolyzes very slow at environmental pHs with half-lives greater than 100 days.

Description of key information

Key value for chemical safety assessment

Half-life for hydrolysis:
100 d
at the temperature of:
25 °C

Additional information

Half-life for hydrolysis is greater than 100 days.