Registration Dossier
Registration Dossier
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EC number: 203-698-7 | CAS number: 109-72-8
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Additional information:
- Migrated from Short description of key information:
n-Butyl lithium is pyrophoric and would react violently in contact on exposure to animal tissues, releasing flammable butane and corrosive (inorganic) lithium hydroxide, and likely starting a fire.
In accordance with column 2 of REACH Regulation 1907/2006/EC Annex VII section 8.3. an in vivo test does not need to be conducted if the available information indicates that the substance should be classified for skin corrosivity, or the substance is a base (pH ≥ 11,5), or the substance is flammable in air at room temperature.
n-Butyl lithium is skin corrosive and spontaneous ignites at room temperature.
Skin sensitization studies in guinea pigs with lithium chloride and lithium carbonate did not reveal sensitizing potential for inorganic lithium compounds. Also butane is not known as sensitizer in context with skin contact due to its very low chemical reactivity.
Justification for classification or non-classification
Based on the available data, n-Butyl lithium is not classified as sensitizer according to Regulation (EC) No 1272/2008 (CLP) or Directive 67/548/EC (DSD) criteria.
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