Registration Dossier
Registration Dossier
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EC number: 203-698-7 | CAS number: 109-72-8
Endpoint summary
Administrative data
Description of key information
Additional information
n-Butyl lithium is pyrophoric and reacts violently with water / air humidity to form butane and lithium hydroxide. Thus, a study on the biodegradation in water of the substance as such is scientifically not justified.
Butane is practically insoluble in water and readily volatilizes at ecological relevant temperatures. Thus, with respect to butane, a study on its biodegradation in water is scientifically not justified.
In accordance with column 2 of REACH Regulation 1907/2006/EC Annex VII section 9.2.1.1, the study “Biodegradation in water: screening test” does not need to be conducted with inorganic substances. Lithium hydroxide is an inorganic substance. Thus, a study on the biodegradation in water of lithium hydroxide is scientifically not justified.
In summary, the study on the biodegradation in water is neither justified for the substance as such nor with its products of hydrolysis (LiOH, butane).
Finally it should be stressed again that n-Butyl lithium may ignite spontaneously in air or on contact with water / air humidity and that therefore a study on "Biodegradation in water: screening test" cannot be performed by standard methods. Spontaneous self-ignition occurred after a sample (n-Butyl lithium 90% in 10% hexane) was poured into a cup used for flash point determination (see disregarded study section 4.11). Two reports on accidents resulting in death are also attached to demonstrate the extreme reactivity. Best measurements for occupational health and safety are required. All unnecessary risk has to be avoided. See section 4.23.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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