Registration Dossier
Registration Dossier
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EC number: 204-493-5 | CAS number: 121-69-7
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- other: Modelling database
- Principles of method if other than guideline:
- Study obtained from Multicase model A33, data from GPMT
- GLP compliance:
- not specified
- Type of study:
- guinea pig maximisation test
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Route:
- other: unspecified
- Vehicle:
- no data
- Concentration / amount:
- not reported
- Route:
- other: no data
- Vehicle:
- no data
- Concentration / amount:
- not reported
- No. of animals per dose:
- not reported
- Vehicle:
- unchanged (no vehicle)
- Reading:
- 1st reading
- Group:
- test chemical
- Clinical observations:
- not sensitising
- Remarks on result:
- other: Reading: 1st reading. Group: test group. Clinical observations: not sensitising.
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- N,N-dimethylaniline was estimated to be non sensitising to skin of guinea pig using the Multicase model A33 from the Danish EPA database.
- Executive summary:
N,N-dimethylaniline was estimated to be non sensitising to skin of guinea pig using the Multicase model A33 from the Danish EPA database.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
N,N-dimethylaniline was estimated to be non sensitising to skin of human or guinea pig using the Multicase model A33 from the Danish EPA database.
Migrated from Short description of key information:
N,N-dimethylaniline was estimated to be non sensitising to skin of human or guinea pig using the Multicase model A33 from the Danish EPA database.
Justification for selection of skin sensitisation endpoint:
N,N-dimethylaniline was estimated to be non sensitising to skin of human or guinea pig using the Multicase model A33 from the Danish EPA database.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
N,N-dimethylaniline was estimated to be non sensitising to skin of human or guinea pig using the Multicase model A33 from the Danish EPA database. Therefore, the substance is not classified as a akin sensitiser.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
