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EC number: 230-989-6 | CAS number: 7394-38-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14 - 16 March 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- yes
- Remarks:
- see principles of method if other than guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- Regulation (EC) No 440/2008
- Deviations:
- yes
- Remarks:
- see principles of method if other than guideline
- Principles of method if other than guideline:
- Due to high water solubility of the test item, estimated in a preliminary test, a modified TG OECD 105 design was conducted. Instead of equilibrating a large amount of test item with water by stirring over several days and subsequently separating the test item from the saturated solution, water was added in a stepwise procedure to a defined amount of test item until complete dissolution occurred.
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- >= 782 g/L
- Conc. based on:
- test mat. (dissolved fraction)
- Temp.:
- 23 °C
- pH:
- 6
- Details on results:
- Preliminary test
The water solubility of the test item was determined to be >1000 g/L.
Main test
The results are given in the table in the next section. The water solubility was determined as the mean of the replicates analysed with HPLC. As this method does not ensure complete saturation of the solution, it is given as minimum value in mass per volume of solution. The test is satisfactory, if the concentrations of the three vessels do not differ by more than 15%. - Conclusions:
- The water solubility of the test item “p-Nitrobenzoic acid, compound with 2,2',2''-nitrilotriethanol (1:1)” (CAS no. 7394-38-9) was determined according to a modified TG OECD 105 design.
The determined water solubility of p-Nitrobenzoic acid was 413 g/L. Based on a p-Nitrobenzoic acid content of 52.8%, the determined water solubility of the test item “p-Nitrobenzoic acid, compound with 2,2',2''-nitrilotriethanol (1:1)” (CAS no. 7394-38-9) is >=782 g/L at pH 6 and at 23°C. - Executive summary:
The water solubility of the test item “p-Nitrobenzoic acid, compound with 2,2',2''-nitrilotriethanol (1:1)” (CAS no. 7394-38-9) was determined according to a modified TG OECD 105 design.
To this end, increasing volumes of water were added in a stepwise procedure, to approximately 1 g of the test item at 22 ± 2 °C until complete dissolution, which occurred after addition of 0.5 mL of water. The concentration of test item was subsequently determined by HPLC with UV detection based on the analysis of the test item component p-nitrobenzoic acid.
The determined concentration of p-Nitrobenzoic acid was 413 g/L. Based on a p-Nitrobenzoic acid content of 52.8%, the determined water solubility of the test item “p-Nitrobenzoic acid, compound with 2,2',2''-nitrilotriethanol (1:1)” is >=782 g/L at pH 6 and at 23°C.
Reference
HPLC determinations:
Test vessel | pH | Analysed concentration A (g/L) | Analysed concentration B (g/L) | Mean (g/L) |
No. 1 | 6 | 402 | 399 | 401 |
No. 2 | 6 | 416 | 425 | 420 |
No. 3 | 6 | 425 | 412 | 419 |
Overall Mean | 413 |
The concentrations of the three vessels differed by 5% (validity criterion given by OECD is met).
The determined concentration of p-Nitrobenzoic acid was 413 g/L. Based on a p-Nitrobenzoic acid content of 52.8%, the determined water solubility of the test item “p-Nitrobenzoic acid, compound with 2,2',2''-nitrilotriethanol (1:1)” (CAS no. 7394-38-9) is >=782 g/L.
Description of key information
The water solubility of the test item “p-Nitrobenzoic acid, compound with 2,2',2''-nitrilotriethanol (1:1)” was determined in a GLP study according to a modified TG OECD 105 design (Klimisch 1, Arcadis, 2017). The determined water solubility of p-Nitrobenzoic acid was 413 g/L. Based on a p-Nitrobenzoic acid content of 52.8%, the determined water solubility of the test item “p-Nitrobenzoic acid, compound with 2,2',2''-nitrilotriethanol (1:1)” is >= 782 g/L at pH 6 and at 23°C.
Key value for chemical safety assessment
- Water solubility:
- 782 g/L
- at the temperature of:
- 23 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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