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EC number: 230-989-6 | CAS number: 7394-38-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 8 - 12 October 2001
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Study according to test guideline OECD203 (not performed according to GLP). The test report is with detailed documentation. Further details on the test item are lacking in the report.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- 1992
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Version / remarks:
- 1992
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: Static
- Controls: A blank of test medium without test substance or other additives served as a control.
- Concentration of vehicle in test medium: Nominal 100 mg/l was prepared by dilution of a stock solution or, in case of poorly soluble compounds, by adding the test substance direcily to the test medium. - Test organisms (species):
- Poecilia reticulata
- Details on test organisms:
- TEST ORGANISM
- Common name: Guppy
- Source: BMG Ecolaboratories
- Age at study initiation (mean and range, SD): not determined
- Length at study initiation (length definition, mean, range and SD): 1-3 cm
- Weight at study initiation (mean and range, SD): not determined
- Method of breeding: Parental and young fish population was held in two 250 I glass aquaria
- Maintenance of the brood fish:
Medium: Continuously aerated and filtered tap water from Schlieren. The bottom of the aquaria was covered with gravel (<1,5 cm). Every month,
one third of the total volume of the aquaria was replaced by fresh tap water.
Feed: Sera micropan, Sera vipan (Sera apanristic GmbH, D-52525 Heinsberg, Germany) daily. The fish were last fed 24 h belore the start of the
definitive test.
Illumination: 14 h a day
Temperature: 23 +/- 2 °C
Health: During 7 days before the definitive test, mortality in the batch of which fish were used for the test was less than 5 %.
FEEDING DURING TEST: not specified - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- 15.3 - 27.8 °F
- Test temperature:
- 22 - 22.5 °C
- pH:
- 8.2 - 8.5
- Dissolved oxygen:
- 6.8 -7.2 mg/l
- Conductivity:
- 510 - 585 uS/cm
- Nominal and measured concentrations:
- 0 and 100 mg/l Nominal
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 1 l aquaria, all-glass
- Aeration: aereated
- No. of organisms per vessel: 7
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Tap water from Schlieren, aerated
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 h light/day
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
TEST CONCENTRATIONS
- only limit test 100 mg/l (nominal) - Key result
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- At the nominal concentration of 100 mg/l none of a total of seven fish died after 96h of exposure. No mortality was also observed in the blank control.
Other toxic effects than mortality, e.g. loss of coordination, hypo- or hyperactivity and swimming on the back, were not observed. - Reported statistics and error estimates:
- Based on the binominal theory, the absence of mortality provides at least 99 % confidence that the LC50 is >100 mg/l.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The no-observed-effect concentration (NOEC) was >=100 mg/l.
100 % mortality (LC100) could not be detected.
Based on the binominal theory, the absence of mortality provides at least 99 % confidence that the LC50 is greater than the applied nominal test concentration of 100 mg/l. - Executive summary:
The acute lethal toxicity of REVATOL NS to Poecitia reticulata (Guppy) was investigated under static exposure conditions over a period of 96 h. The only applied nominal test concentration was 100 mg/l.
No chemical analysis of the test substance concentration was conducted.
At the nominal concentrationof 100 mg/l none of a total of seven fish died after 96h of exposure. No mortality was also observed in the blank control.
Other toxic effects than mortality, e.g. loss of coordination, hypo- or hyperactivity and swimming on the back, were not observed. The no-observed-effect concentration (NOEC) was >=100 mg/l.
100 % mortality (LC100) could not be detected.
Based on the binominal theory, the absence of mortality provides at least 99 % confidence that the LC50 is greater than the applied nominal test concentration of 100 mg/l.
Reference
Description of key information
The no-observed-effect concentration (NOEC) was >=100 mg/l.
Based on the binominal theory, the absence of mortality provides at least 99 % confidence that the LC50 is greater than the applied nominal test concentration of 100 mg/l.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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