Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 221-394-2 | CAS number: 3085-30-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- two-generation reproductive toxicity
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 2008-2009
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 416 (Two-Generation Reproduction Toxicity Study)
- GLP compliance:
- yes
- Remarks:
- The publication describes a study performed under GLP at the Safety Research Institute Kanto Chemical Compounds Co. Ltd, Sapporo Japan
- Limit test:
- no
Test material
- Reference substance name:
- Aluminium sulphate
- EC Number:
- 233-135-0
- EC Name:
- Aluminium sulphate
- Cas Number:
- 10043-01-3
- Molecular formula:
- Al.3/2H2O4S
- IUPAC Name:
- aluminium sulphate
- Details on test material:
- Not reported
Constituent 1
- Specific details on test material used for the study:
- lot: 007X1828
purity: 98.5%
storange of the sample: cool and dark in sealed container
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Atsugu Breeding Center, Charles River Laboratories Japan Inc. Yokohama, Japan
- Females: no data
- Age at study initiation: (P) 5 weeks
- Weight at study initiation: (P) Males: ca 180 g; Females: ca 120 g; (F1) Males: 80 g; Females: 70 g Values taken from figures in the publication)
- Fasting period before study: no
- Housing:
- Diet standard rat diet (CRF-1 Oriental Yeast Co. Ltd, Tokyo, Japan containing 25-29 ug/g Al) ad libitum
- Water: ionexchanged water containing the substance ad libitum
- Acclimation period: 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21-25 °C
- Humidity (%): 35-59 %
- Air changes (per hr): 10-15/h
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: drinking water
- Details on exposure:
- WATER PREPARATION
- Rate of preparation of diet (frequency): every 6 days
- Storage temperature of water: cooled
- FRequency based on stability for 4 days at room temperature and 6 days refrigerated (tested at 0.1, 0.6 and 15 mg/mL)
- Details on mating procedure:
- - M/F ratio per cage: 1/1
- Length of cohabitation: 2 weeks
- Proof of pregnancy: vaginal plug / sperm in vaginal smear referred to as day 0 of pregnancy
- After 2 weeks
- Further matings after two unsuccessful attempts: not indicated - Analytical verification of doses or concentrations:
- yes
- Details on analytical verification of doses or concentrations:
- In first and last preparation and every three months by HPLC (97.5-106.3% of nominal)
Drinking water was below the LOQ (0.5 ug/mL) - Duration of treatment / exposure:
- P: 10 weeks and during mating gestation and lactation (parental males were necropsied at the same time as females)
F1: after weaning until mating and during mating gestation and lactation
Necropsy for non-selected F1 and F2 pups on day 26 after weaning - Frequency of treatment:
- continuously
- Details on study schedule:
- - F1 parental animals not mated until unknown] weeks after selected from the F1 litters.
- Selection of parents from F1 generation when pups were 21-25 days of age.
Doses / concentrationsopen allclose all
- Dose / conc.:
- 0.12 mg/L drinking water
- Dose / conc.:
- 0.6 mg/L drinking water
- Dose / conc.:
- 3 mg/L drinking water
- No. of animals per sex per dose:
- 24 males and 24 females for mating in P and F1 generation
- Control animals:
- other: ion exchanged drinking water
- Details on study design:
- - Dose selection rationale: based on a pre-test during 6-8 weeks, mating gestation and until day 4 post partum (at 1, 3, 10 and 30 mg/L in drinking water, NOAEL 3 mg/L)
Examinations
- Parental animals: Observations and examinations:
- CAGE SIDE OBSERVATIONS: Yes
- Time schedule: twice daily
DETAILED CLINICAL OBSERVATIONS: No data
BODY WEIGHT: Yes
- Time schedule for examinations: weekly (females during gestation on day 0, 7, 14 and 20; during lactation on day 0, 7, 14 and 21)
FOOD CONSUMPTION : Yes
- Time schedule for examinations:weekly (females during gestation on day 0, 7, 14 and 20; during lactation on day 0, 7, 14 and 21)
WATER CONSUMPTION AND COMPOUND INTAKE (if drinking water study): Yes
- Time schedule for examinations: twice weekly females during gestation on day 0,4, 7, 11, 14, 17 and 20; during lactation on day 0, 4, 7, 11, 14, 17, 19 and 21)
- Calculation intake: based on mean values for body weight and water intake per group
OTHER: - Oestrous cyclicity (parental animals):
- 2 weeks pre-mating and during cohabitation (4-6 days oestrus cycle considered as normal)
- Sperm parameters (parental animals):
- Parameters examined in all adult male parental generations:
testis weight, epididymis weight, sperm count in testes, sperm count in epididymides, enumeration of cauda epididymal sperm reserve, sperm motility, sperm morphology - Litter observations:
- STANDARDISATION OF LITTERS
- Performed on day 4 postpartum: yes to 4 males and 4 females
excess pups were killed and necropsied (gross external and internal observations)
PARAMETERS EXAMINED
The following parameters were examined in F1 / F2 offspring:
number and sex of pups, stillbirths, live births, postnatal mortality, presence of gross anomalies, body weight, physical or behavioural abnormalities, pinna unfolding, anogenital distance (AGD)(
In one male + one female pup per litter:onset and completion of incisor eruption, eye opening, perpetual separation and vaginal opening
GROSS EXAMINATION OF DEAD PUPS: yes, for external and internal abnormalities
ASSESSMENT OF DEVELOPMENTAL NEUROTOXICITY: no
ASSESSMENT OF DEVELOPMENTAL IMMUNOTOXICITY: no
ASSESSMENT OF BEHAVIOURAL EFFECTS:
On day 5, 8 and 18 in one male + one female pup per litter: surface rightening reflex, negative geitaxis, mid-air rightening reflex
After 4 weeks in 10/sex/group: motoractivity and swim test (T-maze) - Postmortem examinations (parental animals):
- SACRIFICE
- Male animals: All surviving animals at the same time as the females]
- Maternal animals: All surviving animals depending on oestrus cycle status after weaning
GROSS NECROPSY
- Gross necropsy in all animals consisted of external and internal examinations including the cervical, thoracic, and abdominal viscera; females counts of implementation sites; males testis and epididymides preservation:
HISTOPATHOLOGY / ORGAN WEIGHTS:
From all animals: weights of brain, pituitary, thyroids, thymus, liver, kidneys, spleen, adrenals, testes, epididymides,, seminal vessels, prostate, uterus, ovaries
From control and high dose (+ all females with abnormalities + non copulating animals + animals with abnormalities ate the sex organs): histopathology of testes, epididymides,, seminal vessels, coagulating gland, ventral prostate, uterus, ovaries and vagina
From 10 females from control and high dose group: count of premordial follicles in the right ovary
- Postmortem examinations (offspring):
- SACRIFICE
- The F1 offspring not selected as parental animals and all F2 offspring were sacrificed at 26 days of age.
- These animals were subjected to postmortem examinations (macroscopic and/or microscopic examination) as follows:
GROSS NECROPSY
- Gross necropsy consisted of external and internal examinations
HISTOPATHOLOGY / ORGAN WEIGTHS
Organ weight of for 1 male + 1 female F1/F2 weanling/litter: brain, thymus, liver, kidneys, spleen, adrenals, testes, epididymides,, seminal vessels, prostate, uterus, ovaries
Microscopic examination of 10 males + females in control and high dose group of spleen and liver - Statistics:
- Bartlett's test, Dunnett's test, Kruskal-Wallis test, Mann-Whitney's U-test, Fisher exact test, Student t-test (f-test)
- Reproductive indices:
- Copulation Index; Fertility Index; Gestation Index; Delivery Index
- Offspring viability indices:
- Viability Index on post-natal day 0, 4 and 21
Results and discussion
Results: P0 (first parental generation)
General toxicity (P0)
- Clinical signs:
- no effects observed
- Mortality:
- mortality observed, non-treatment-related
- Description (incidence):
- P0: 1 female at 0.6 mg/L (mass)
- Body weight and weight changes:
- effects observed, non-treatment-related
- Description (incidence and severity):
- Decreased body weight at 3 mg/L during week 2 and 3 in males = females
- Food consumption and compound intake (if feeding study):
- effects observed, treatment-related
- Description (incidence and severity):
- Males: sign decreased at 0.6 and 3 mg/L during week 1; sign decreased during week 8 and 13-14 at 3 mg/L
Females: sign decreased at 3 mg/L during week 1; sign decreased during week 3 of lactation at 0.6 and 3 mg/L - Water consumption and compound intake (if drinking water study):
- effects observed, treatment-related
- Description (incidence and severity):
- significantly decreased in all dose groups (related to the acidity of the formulated water)
- Ophthalmological findings:
- not examined
- Haematological findings:
- not examined
- Clinical biochemistry findings:
- not examined
- Urinalysis findings:
- not examined
- Behaviour (functional findings):
- not examined
- Immunological findings:
- not examined
- Histopathological findings: non-neoplastic:
- no effects observed
- Description (incidence and severity):
- No treatment related effects
Reproductive function / performance (P0)
- Reproductive function: oestrous cycle:
- no effects observed
- Description (incidence and severity):
- No treatment related effects
- Reproductive function: sperm measures:
- effects observed, treatment-related
- Description (incidence and severity):
- at 3 mg/L sign decrease in cauda epidydimal sperm (control 268E06/cauda; treated 254E06/cauda)
- Reproductive performance:
- no effects observed
- Description (incidence and severity):
- Copulation Index (%)
Males: 91.7, 91.7, 100. 91.7 at 0, 0.12,0.6 and 3 mg/L
Females:95.8, 100, 100, 100 at 0, 0.12,0.6 and 3 mg/L
Fertility Index (%):
Males: 95.5, 90,9. 100, 95.5 at 0, 0.12,0.6 and 3 mg/L
Females: 95.7, 91.7, 100, 91.8 at 0, 0.12,0.6 and 3 mg/L
Gestation Index (%): 100, 95.5, 95.7, 95.7 at 0, 0.12,0.6 and 3 mg/L
Delivery Index (%): 94.3, 88.6, 90.7, 92.0 at 0, 0.12,0.6 and 3 mg/L
Effect levels (P0)
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- 13.5 mg/kg bw/day (actual dose received)
- Based on:
- element
- Sex:
- male
- Basis for effect level:
- food consumption and compound intake
- water consumption and compound intake
- organ weights and organ / body weight ratios
- reproductive function (sperm measures)
- Dose descriptor:
- NOAEL
- Effect level:
- 8.06 mg/kg bw/day (actual dose received)
- Based on:
- element
- Sex:
- female
- Basis for effect level:
- food consumption and compound intake
- water consumption and compound intake
- Remarks on result:
- other: related to the acidity of the drinking water
Target system / organ toxicity (P0)
- Critical effects observed:
- yes
- Lowest effective dose / conc.:
- 31.2 mg/kg bw/day (actual dose received)
- System:
- male reproductive system
- Organ:
- cauda epididymis
- Treatment related:
- no
- Dose response relationship:
- no
- Relevant for humans:
- no
Results: P1 (second parental generation)
General toxicity (P1)
- Clinical signs:
- no effects observed
- Mortality:
- mortality observed, non-treatment-related
- Description (incidence):
- F1: 1 male at 0.12 mg/L and 1 male at 3 mg/L
- Body weight and weight changes:
- no effects observed
- Description (incidence and severity):
- No significant difference with controls
Females at 3 mg/L showed increased body weight during week 6-8 - Food consumption and compound intake (if feeding study):
- effects observed, treatment-related
- Description (incidence and severity):
- Males: sign decreased during week 10 at 0.6 and 3 mg/L
Females: sign decreased during week 3 of lactation at 0. and 3 mg/L
Incidental increases were also reported - Water consumption and compound intake (if drinking water study):
- effects observed, treatment-related
- Description (incidence and severity):
- Males: sign decreased at 0.6 and 3 mg/L; sign decreased during week 3-6, 8 and 10 at 0.12 mg/L
Females: sign decreased at 3 mg/L; sign decreased during week 10 of dosing and 3 of lactation at 0.6 mg/L; sign decreased during week 9-10 at 0.12 mg/L
Effects related to the acidity of the formulations - Ophthalmological findings:
- not examined
- Haematological findings:
- not examined
- Clinical biochemistry findings:
- not examined
- Urinalysis findings:
- not examined
- Behaviour (functional findings):
- no effects observed
- Description (incidence and severity):
- No difference with control animals
- Immunological findings:
- not examined
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Description (incidence and severity):
- No difference with control animals.
- Gross pathological findings:
- no effects observed
- Description (incidence and severity):
- No treatment related effects
- Neuropathological findings:
- not examined
- Histopathological findings: non-neoplastic:
- no effects observed
- Description (incidence and severity):
- No treatment related effects
Reproductive function / performance (P1)
- Reproductive function: oestrous cycle:
- no effects observed
- Description (incidence and severity):
- No treatment related effects
- Reproductive function: sperm measures:
- no effects observed
- Description (incidence and severity):
- No treatment related effects
- Reproductive performance:
- no effects observed
- Description (incidence and severity):
- Copulation Index (%)
Males: 95.8. 91.3, 95.8, 87.5 at 0, 0.12,0.6 and 3 mg/L
Females:100, 95.8, 100, 95.8 at 0, 0.12,0.6 and 3 mg/L
Fertility Index (%):
Males:91.3, 81.0, 91.3, 95.2 at 0, 0.12,0.6 and 3 mg/L
Females: 91.7, 82.6, 91.7, 91.3 at 0, 0.12,0.6 and 3 mg/L
Gestation Index (%): 100, 94.7, 100, 100 at 0, 0.12,0.6 and 3 mg/L
Delivery Index (%): 94.0, 87.5, 91.4, 94.6 at 0, 0.12,0.6 and 3 mg/L
Effect levels (P1)
- Dose descriptor:
- NOAEL
- Effect level:
- >= 9.78 - <= 14 mg/kg bw/day (actual dose received)
- Based on:
- element
- Sex:
- male/female
- Basis for effect level:
- food consumption and compound intake
- water consumption and compound intake
- Remarks on result:
- other: No treatment related effects
Target system / organ toxicity (P1)
- Critical effects observed:
- no
Results: F1 generation
General toxicity (F1)
- Clinical signs:
- no effects observed
- Description (incidence and severity):
- see P1
- Mortality / viability:
- mortality observed, non-treatment-related
- Description (incidence and severity):
- see P1
Viability Index:
post natal day 0 (%): 100, 99.3, 99.7 and 99,5 at 0, 0.12, 0.6 and 3 mg/L
post natal day 4 (%): 98.7, 95.2, 98.8 and 98.0 at 0, 0.12, 0.6 and 3 mg/L
postnatal day 21 (%): 99.4, 100, 100 and 99.4 at 0, 0.12, 0.6 and 3 mg/L - Body weight and weight changes:
- no effects observed
- Description (incidence and severity):
- see P1
post natal day 21: at 3 mg/L sign decreased body weight in both sexes - Food consumption and compound intake (if feeding study):
- effects observed, treatment-related
- Description (incidence and severity):
- see P1
- Water consumption and compound intake (if drinking water study):
- effects observed, treatment-related
- Description (incidence and severity):
- see P1
- Ophthalmological findings:
- not examined
- Haematological findings:
- not examined
- Clinical biochemistry findings:
- not examined
- Urinalysis findings:
- not examined
- Sexual maturation:
- no effects observed
- Organ weight findings including organ / body weight ratios:
- effects observed, non-treatment-related
- Description (incidence and severity):
- see P1
sign decreased abs thymus and spleen weight in both sexes at 3 mg/L
sign decreased abs kidney, testes and epididymus weight in males at 3 mg/L
sign decreased abs uterus weight in females at 0.6 and 3 mg/L
sign increased rel brain weight in both sexes at 3 mg/L - Gross pathological findings:
- no effects observed
- Description (incidence and severity):
- see P1
No treatment related effects - Histopathological findings:
- no effects observed
- Description (incidence and severity):
- see P1
No treatment elated effects in liver and spleen - Other effects:
- effects observed, treatment-related
- Description (incidence and severity):
- Delayed vaginal openeing in females at 3 mg/L
No other treatment related developmental effects
Developmental neurotoxicity (F1)
- Behaviour (functional findings):
- no effects observed
- Description (incidence and severity):
- No treatment related behavioural effects (no dose response)
Developmental immunotoxicity (F1)
- Developmental immunotoxicity:
- not examined
Effect levels (F1)
open allclose all
- Key result
- Dose descriptor:
- NOAEL
- Generation:
- F1
- Effect level:
- 13.5 mg/kg bw/day (actual dose received)
- Based on:
- element
- Sex:
- female
- Basis for effect level:
- body weight and weight gain
- organ weights and organ / body weight ratios
- other: developmental toxicity (vaginal opening delayed)
- Key result
- Dose descriptor:
- NOAEL
- Generation:
- F1
- Effect level:
- 8.06 mg/kg bw/day (actual dose received)
- Based on:
- element
- Sex:
- male
- Basis for effect level:
- body weight and weight gain
- organ weights and organ / body weight ratios
Results: F2 generation
General toxicity (F2)
- Clinical signs:
- not specified
- Mortality / viability:
- mortality observed, non-treatment-related
- Description (incidence and severity):
- Viability Index:
post natal day 0 (%): 99.7, 99.6, 99.4 and 99.7 at 0, 0.12, 0.6 and 3 mg/L
post natal day 4 (%): 94.7, 98.1, 99.1and 99.0 at 0, 0.12, 0.6 and 3 mg/L
postnatal day 21 (%): 100, 98.6, 100 and 100 at 0, 0.12, 0.6 and 3 mg/L - Body weight and weight changes:
- effects observed, treatment-related
- Description (incidence and severity):
- post natal day 21: at 3 mg/L sign decreased body weight in females
- Food consumption and compound intake (if feeding study):
- not specified
- Ophthalmological findings:
- not examined
- Haematological findings:
- not examined
- Clinical biochemistry findings:
- not examined
- Urinalysis findings:
- not examined
- Sexual maturation:
- no effects observed
- Organ weight findings including organ / body weight ratios:
- effects observed, treatment-related
- Description (incidence and severity):
- sign decreased abs spleen, abs thymus and rel brain weight in males at 3 mg/L
sign decreased abs liver and epididymus weight in males at 3 mg/L
sign decreased abs spleen, ovary and uterus weight in females at 3 mg/L
sign decreased abs/rel liver weight in females at 3 mg/L
sign increased rel brain weight in females at 3 mg/L - Gross pathological findings:
- no effects observed
- Description (incidence and severity):
- No treatment related effects
- Histopathological findings:
- no effects observed
- Description (incidence and severity):
- No treatment related effects in liver and spleen
- Other effects:
- no effects observed
- Description (incidence and severity):
- No treatment related developmental effects
Developmental neurotoxicity (F2)
- Behaviour (functional findings):
- no effects observed
- Description (incidence and severity):
- No treatment related behavioural effects
Developmental immunotoxicity (F2)
- Developmental immunotoxicity:
- not examined
Effect levels (F2)
- Key result
- Dose descriptor:
- NOAEL
- Generation:
- F2
- Effect level:
- >= 9.78 - <= 14 mg/kg bw/day (actual dose received)
- Based on:
- element
- Sex:
- male/female
- Basis for effect level:
- body weight and weight gain
- organ weights and organ / body weight ratios
Overall reproductive toxicity
- Reproductive effects observed:
- yes
- Lowest effective dose / conc.:
- 31.2 mg/kg bw/day (actual dose received)
- Treatment related:
- yes
- Relation to other toxic effects:
- reproductive effects as a secondary non-specific consequence of other toxic effects
- Dose response relationship:
- yes
- Relevant for humans:
- yes
Applicant's summary and conclusion
- Conclusions:
- In parental animals the most prominent effect of the substance was the decreased water intake (most likely due to the acidity of the formulation). THis has lead to effects on food intake and body weight at 3 mg/L. The NOAEL for parental toxicity is therefore set at 8.06 mg/kg bw in a worst case approch
Effects on sperm parameters were seen in parental males (P0) at 3 mg/L. No effects on reproduction were seen in the P0 and P1 generation. The NOAEL for reproduction toxicity is set at 8.06 mg/kg bw in a worst case approch
In the offspring (F1 and F2) effects were limited to a lowered body weight and some changes in organ weights at 3 mg/L. Delayed valginal opening was observed in F1 females at 3 mg/L. The NOAEL for developmental effects is therefore set at 8.06 mg/kg bw. - Executive summary:
In a two-generation reproductive toxicity study, male and female rats were given aluminium sulfate (AS) in drinking water at 0, 120, 600 or 3000 ppm. AS reduced water consumption in all treatment groups, and body weight was transiently decreased in the 3000 ppm group. In the F1 and F2 pups, preweaning body weight gain was inhibited at 3000 ppm, and the liver and spleen weight was decreased at weaning. At this dose, vaginal opening was slightly delayed. There were no compound-related changes in other reproductive/developmental parameters, including developmental neurobehavioral endpoints. The data indicated that the NOAEL of AS in this two-generation study is 600 ppm for parental systemic toxicity and reproductive/developmental toxicity. The total ingested dose of aluminium from drinking water and food (standard rat diet, containing 25-29 ppm of aluminium) combined for this 600 ppm group was calculated to be 8.06 mg Al/kg bw/day.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.