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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 221-394-2 | CAS number: 3085-30-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 61 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- other: based on lowest derived occupational exposure limit for butan-1-ol
- Overall assessment factor (AF):
- 1
- Dose descriptor starting point:
- other: occupational exposure limit
- Value:
- 61 mg/m³
- Explanation for the modification of the dose descriptor starting point:
The value derived is based on the worst case time-weighted average concentration (8-h working period) as derived by Belgium, Finland, Italy and Switzerland of 61 mg/m3. This assessment is based on irritant effects to the eyes, no further details are available, but occupational limit values in general take into account several assessment factors. Therefore no additional assessment factors are included.
- AF for dose response relationship:
- 1
- AF for differences in duration of exposure:
- 1
- Justification:
- The occupational exposure limit for inhalation is based on exposure during work for 8 h, no further assessment factor is needed.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- The occupational exposure limit for inhalation is based on exposure during work for 8 h, no further assessment factor is needed.
- AF for other interspecies differences:
- 1
- Justification:
- The occupational exposure limit for inhalation is based on exposure during work for 8 h, no further assessment factor is needed.
- AF for intraspecies differences:
- 1
- Justification:
- The occupational exposure limit for inhalation is based on exposure during work for 8 h, no further assessment factor is needed.
- AF for the quality of the whole database:
- 1
- Justification:
- The occupational exposure limit for inhalation is based on exposure during work for 8 h, no further assessment factor is needed. This value is based on evaluation of public literature
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 61 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- other: based on lowest derived occupational exposure limit for butan-1-ol
- Overall assessment factor (AF):
- 1
- Dose descriptor:
- other: occupational exposure limit
- Value:
- 61 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- The occupational exposure limit for inhalation is based on exposure during work for 8 h, no further assessment factor is needed.
- AF for differences in duration of exposure:
- 1
- Justification:
- The occupational exposure limit for inhalation is based on exposure during work for 8 h, no further assessment factor is needed.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- The occupational exposure limit for inhalation is based on exposure during work for 8 h, no further assessment factor is needed.
- AF for other interspecies differences:
- 1
- Justification:
- The occupational exposure limit for inhalation is based on exposure during work for 8 h, no further assessment factor is needed.
- AF for intraspecies differences:
- 1
- Justification:
- The occupational exposure limit for inhalation is based on exposure during work for 8 h, no further assessment factor is needed.
- AF for the quality of the whole database:
- 1
- Justification:
- The occupational exposure limit for inhalation is based on exposure during work for 8 h, no further assessment factor is needed. This value is based on evaluation of public literature
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 6.25 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 200
- Dose descriptor starting point:
- NOAEL
- Value:
- 125 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 1 250 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Based the effects of butan-1-ol using absorption percentages of 100% for oral and 10% for dermal absorption
- AF for dose response relationship:
- 1
- Justification:
- The dose response relationship is considered unremarkable, therefore no additional factor is used.
- AF for differences in duration of exposure:
- 2
- Justification:
- subchronic to chronic
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- default allometric scaling factor for rat to human
- AF for other interspecies differences:
- 2.5
- Justification:
- default factor for differences in metabolism (worst case as the metabolism of butanol in humans and rats is very similar)
- AF for intraspecies differences:
- 5
- Justification:
- default value for worker exposure
- AF for the quality of the whole database:
- 2
- Justification:
- data based on literature sources
- AF for remaining uncertainties:
- 1
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Additional information - General Population
Consumer exposure is expected only due to use of aluminium tributanolate in cosmetics and pharmaceutical products. These uses are covered by different legislation and are not required to be included in the chemical safety report according to REACH Article 2, paragraph 5(a).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.