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Diss Factsheets
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EC number: 214-353-5 | CAS number: 1122-58-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The acute oral LD50 in rats is 140 mg/kg bw, and the acute dermal LD50 in rabbits is 90 mg/kg bw. The acute inhalation LC50 of a structural analogue substance (4-AP) is 0.53 mg/L (0.00053 mg/m3).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 140 mg/kg bw
- Quality of whole database:
- adequate
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 0.001 mg/m³ air
- Quality of whole database:
- adequate
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 90 mg/kg bw
- Quality of whole database:
- adequate
Additional information
The acute oral LD50 for DMAP in rats is 140 mg/kg bw in the key in vivo study, and is supported by several non-GLP studies in which the LD50 in rats is between 100 and 500 mg/kg bw.
The acute dermal LD50 in rabbits is 90 mg/kg bw in the key study, and is generally supported by additional non-GLP studies in rabbits and guinea pigs in which the LD50 is in the range of 50 to 200 mg/kg bw.
A skin corrosion study in rabbits is also informative, in that all 6 rabbits died within 4 hours after occlusive dermal exposure (of intact and abraded skin) to 167 to 250 mg/kg bw DMAP. However, the acute dermal toxicity/corrosion protocols employed are more aggressive than those of current guidelines, in that the skin of half the animals was abraded which enhances absorption.
The acute inhalation LC50 of a structural analogue substance (4-AP) is 0.53 mg/L (0.00053 mg/m3).
Justification for selection of acute toxicity – oral endpoint
Guideline study under GLP
Justification for selection of acute toxicity – inhalation endpoint
experimental study of structural analogue
Justification for selection of acute toxicity – dermal endpoint
Guideline study under GLP
Justification for classification or non-classification
According to Regulation EC. No. 1272/2008, the substance is classified as Category 3 for Acute Oral Toxicity, as the LD50 in rats is 140 mg/kg bw. This falls in the range of 50 to 300 mg/kg bw for Category 3.
The substance is classified as Category 2 for Acute Dermal Toxicity, as the key LD50 value in rabbits is 90 mg/kg bw. This falls in the range of 50 to 200 mg/kg bw for Category 2.
The substance is classified as Category 3 for Acute Inhalation Toxicity, as the LC50 of a structural analogue substance (4-AP) is 0.53 mg/L. This falls in the range of 0.5 to 1.0 mg/L for Category 3.
DMAP is classified for specific target organ toxicity (neurotoxicity), single exposure (STOT-SE), based on its activity as a potassium channel blocker in neurons. Frequent findings of DMAP (and 4AP) exposure in mammals and birds are tremors, convulsions, and death. This neurotoxicity effect is not addressed by any other hazard classification. It qualifies as Category 1, based on the existence of “reliable, good quality” human data (on 4AP) suggesting that functional disturbances can be “significant and/or severe” (ECHA, 2015).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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