Registration Dossier
Registration Dossier
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EC number: 208-704-1 | CAS number: 538-75-0
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Dicyclohexylcarbodiimide - identification
- Author:
- Institut für Arbeitsschutz der Deutschen Gesetzlichen Unfallversicherung (IFA)
- Year:
- 2 012
- Bibliographic source:
- Gestis Substance Database - Projektgebundene Literaturliste Nr. 1
Materials and methods
- Principles of method if other than guideline:
- Not available
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Dicyclohexylcarbodiimide
- EC Number:
- 208-704-1
- EC Name:
- Dicyclohexylcarbodiimide
- Cas Number:
- 538-75-0
- Molecular formula:
- C13H22N2
- IUPAC Name:
- N,N'-dicyclohexylcarbodiimide
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
Results and discussion
Any other information on results incl. tables
In a dermal test on guinea pigs, 1 drop of the neat substance (probably of the molten substance) caused massive reddening and moderate formation of edema within 24 hours which persisted for a further 24 hours. The reddening was still moderately pronounced following 1 week, the edema were diminished. After 2 weeks there was only still slight reddening but complete hair loss.
In experiments on further guinea pigs, a few drops (probably of the molten mass) caused death after less than 24 hours (LD50 value smaller than 0.1 ml/kg bw). In general, the substance was described as moderately through to severely irritating to the skin and absorbable through the skin.
Applicant's summary and conclusion
- Interpretation of results:
- toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance is officially classified as toxic in contact with skin.
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