Registration Dossier
Registration Dossier
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EC number: 208-704-1 | CAS number: 538-75-0
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- 1. SOFTWARE : EPI-SUITE EPA (USA)
2. MODEL: ECOSAR v1.11
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
CAS Number: 538-75-0
SMILES: N(=C=NC(CCCC1)C1)C(CCCC2)C2
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL: The QMRF is available in "Attached justification".
5. APPLICABILITY DOMAIN : The QPRF is available in 'Attached justification'.
6. ADEQUACY OF THE RESULT : The QPRF is available in 'Attached justification'. - Guideline:
- other: REACH Guidance on QSARs R.6
- GLP compliance:
- no
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.032 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: calculated value.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The calculated 96h-EC50 of the test item in algae is 0.032 mg/L.
- Executive summary:
ECOSAR v1.11 calculation of the 96h-EC50 in algae was used. According to this method, the substance has a 96h-EC50 = 0.032 mg/L in green algae.
Reference
ECOSAR v1.11 predicted that the substance has a 96h-EC50 = 0.032
mg/L in green algae.
Description of key information
Key study: Method according to OECD 201, GLP study. The 72h-ELr50 of the test item in green algae was found to be 6.84 mg/L (95% CL: 6.27 - 7.42) and the NOELR was 3.1 mg/L (nominal concentrations, based on growth rate).
Supporting study: ECOSAR v1.11, accepted calculation method. The substance has a predicted 96h-EC50 = 0.032 mg/L in green algae.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 6.84 mg/L
- EC10 or NOEC for freshwater algae:
- 3.1 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
