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Diss Factsheets
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EC number: 615-240-7 | CAS number: 710292-85-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 850.1075 (Freshwater and Saltwater Fish Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Details on sampling:
- A concentration related turbidity and sedimentation of the test item was observed throughout the test period.
pH, temperature and oxygen saturation were measured in all vessels at the beginning of the test and at every 24h interval.
No control analyses were conducted according to guidleine recommendatiosn. All effect values are based onn nominal concentrations.
Total hardness, residual chlorine and TOC of the dilution water were determined at the beginning of the test. Room temperature was continuously recorded. - Details on test solutions:
- No vehicles used to dissolve test item.
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- - All fish originated from same supplier
- Holding was performed at 12+/-2 degreews celsius. Water was changed at least once per week.
- Only fish with at least 12 days of acclimatisation and mortality <5% were used in the study.
- Tap water of local origin used for holding and testing - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- 40-180 mg CaCO3/L
- Test temperature:
- 12 +-2 degrees Celcius
- pH:
- 6-8
- Dissolved oxygen:
- <2 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 15L glass aquaria with glass tops (closed)
- Material, size, headspace, fill volume:
- Aeration: Gentle aeration provided
- Type of flow-through (e.g. peristaltic or proportional diluter):
- Renewal rate of test solution (frequency/flow rate):
- No. of organisms per vessel: 7
- No. of vessels per concentration (replicates): 2 per concentration
- No. of vessels per control (replicates): 2
- No. of vessels per vehicle control (replicates): 2
- Biomass loading rate:
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Tapwater
- Total organic carbon: <2mg/L
- Particulate matter: Suspended solid (test material)
- Chlorine: <0.05 mg/L
- Intervals of water quality measurement: Yearly
OTHER TEST CONDITIONS
- Adjustment of pH:Adjusted to pH7 with hydrochloric acid
TEST CONCENTRATIONS
- Test concentrations: 6.25, 12.5, 25, 50, 100 mg/L - Reference substance (positive control):
- no
- Duration:
- 6 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- dissolved
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: N/A
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- dissolved
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: N/A
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- dissolved
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: N/A
- Duration:
- 72 h
- Dose descriptor:
- LC50
- Effect conc.:
- 52 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- dissolved
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 47.8-56.0
- Remarks:
- 95% confidence interval
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 50 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- dissolved
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 45.7-53.6
- Remarks:
- 95% confidence interval
- Details on results:
- Water quality parameters (temperature, pH, O2saturation, total hardness, TOC and residual chlorine were determined to be within acceptable limits.
- Reported statistics and error estimates:
- p = 95%
- Conclusions:
- Under the conditions of the study, the LC50 after 96 hrs was determined at a concentration of 50 mg/l of the test substance.
Reference
Description of key information
Under the conditions of the study, the LC50 after 96 hrs was determined at a concentration of 50 mg/l of the test substance.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- 50 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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