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EC number: 457-690-5 | CAS number: 23432-65-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 Aug - 18 Oct 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Hessisches Ministerium für Umwelt, Landwirtschaft und Forsten
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: control, 100 mg/L (after stirring for 3 d)
- Sampling method: Duplicate samples were taken at test start and test end.
- Sample storage conditions before analysis: samples were analysed directly - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: Since the test item hydrolyses in water quickly, in the present test the hydrolysis products of nominal 100 mg/L were tested. For preparation of test solutions 602 mg test substance was mixed into 6 L test medium by intense stirring for 72 h. In a second experiment with identical conditions a stirring period of 24 h was chosen.
- Eluate: no
- Differential loading: no
- Controls: yes, test water control - Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- TEST ORGANISM
- Common name: rainbow trout
- Source: Forellenzuchtbetrieb Tautenhahn, Trostadt, Germnay
- Age at study initiation: juveniles
- Length at study initiation (length definition, mean, range and SD): 4.3 ± 0.2 cm
- Weight at study initiation (mean and range, SD): 0.7 ± 0.2 g
- Feeding during test: none
ACCLIMATION
- Acclimation period: 14 d
- Acclimation conditions (same as test or not): same as test
- Type and amount of food: commercial fish diet until 1 d prior to exposure
- Health during acclimation (any mortality observed): no mortality observed, all fish in healthy conditions - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- 2.5 mmol/L (= 250 mg/L) as CaCO3
- Test temperature:
- 16 - 17 °C
- pH:
- 7.6 - 8.1
- Dissolved oxygen:
- 8.6 - 9.5 mg O2/L
- Nominal and measured concentrations:
- nominal: control, 100 mg/L
measured: In the mean 89% of nominal were found. Thus, during the test duration the fish were exposed to the hydrolysis products of a mean of 89 mg/L. - Details on test conditions:
- TEST SYSTEM
- Test vessel: Aquaria
- Material, size, headspace, fill volume: glass, 8 L, headspace: 2.5 L, fill volume: 5 L
- Aeration: slightly aerated
- No. of organisms per vessel: 7
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: deionised water
- Alkalinity: 0.8 mmol/L
- Ca/mg ratio: 4:1 (based on molarity)
- Conductivity: < 5 µS/cm-1
- Culture medium different from test medium: no
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 h light / 8 h dark
- Light intensity: 560 - 800 lux
EFFECT PARAMETERS MEASURED
- Mortality and Symptoms of Intoxication: after 2, 24, 48, 72 and 96 h
TEST CONCENTRATIONS
- Spacing factor for test concentrations: not applicable, limit test
- Range finding study: A range-finding study was performed but not reported in detail. - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- but the exposure was to hydrolysis products
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- but the exposure was to hydrolysis products
- Basis for effect:
- mortality (fish)
- Details on results:
- - Behavioural abnormalities: not observed
- Mortality of control: 0%
- Other: A stirring period of 24 h did not affect the results of the study (based on data from an additional experiment) - Validity criteria fulfilled:
- yes
- Conclusions:
- A 96 h LC50 of > 100 mg/L has been determined for the effects of the test substance on mortality of Oncorhynchus mykiss. The results are expressed relative to nominal concentrations of the test substance. However, the substance is subject to rapid hydrolysis and under the test conditions it is therefore likely that exposure will have been to its hydrolysis products.
Reference
Description of key information
LC50 (96 h) > 100 mg/L based on mortality of Oncorhynchus mykiss (EU Method C.1)
Key value for chemical safety assessment
Additional information
One experimental study is available investigating the short-term toxicity of methyl-N-{[dimethoxy(methyl)silyl]methyl}carbamate (CAS 23432 -65 -7) to freshwater fish (Hertl, 2002). This study was performed according to EU Method C.1 (GLP). Oncorhynchus mykiss was exposed to a limit concentration of nominal 100 mg/L. Analysis of the dissolved organic carbon (DOC) revealed a mean recovery of 89%. Since the substance is expected to hydrolyse rapidly in contact with water (DT50: 1.9 h at 20 - 25 °C, pH 7), the result from this study mainly investigated the possible effects of the hydrolysis products (Methyl-N-{[dihydroxy(methyl)silyl]methyl}carbamate und methanol). After an exposure of 96 h no mortality was observed resulting in a LC50 of > 100 mg/L.
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