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EC number: 401-300-8 | CAS number: 86168-95-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
- Acute oral toxicity (OECD guideline 401): LD50 > 5000 mg/kg bw (CIBA-GEIGY Ltd., 850040, 1985)
- Acute dermal toxicity (OECD guideline 402): LD50 > 2000 mg/kg bw (CIBA-GEIGY Ltd., 850043, 1985)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Acute oral toxicity
The acute oral toxicity of the test substance was assessed in rats following OECD guideline 401 (CIBA-GEIGY Ltd., 850040, 1985) and under GLP-like quality controlled conditions. In the limit test, a single dose of 5000 mg/kg body weight in distilled water containing 0.5% carboxymethylcellulose and 0.1% polysorbate 80 was applied once by gavage to five male and five female rats following an observation period of 14 days. No mortality occurred within the timeframe of the study. Dyspnea, exophthalmos, ruffled fur, and curved body position were seen, being common symptoms in acute tests. The animals recovered within 13 days. Body weight gain was normal and necropsy did not reveal any abnormalities. Overall, under the chosen test conditions, the test substance was not toxic after single oral administration: Oral LD50 > 5000 mg/kg body weight
Acute dermal toxicity
As a second exposure route acute dermal toxicity was investigated (CIBA-GEIGY Ltd., 850043, 1985). In the study according to OECD guideline 402 and under GLP-like quality assurance, the Standard Acute Method using a single dose of 2000 mg/kg body weight (vehicle: distilled water containing 0.5%carboxymethylcellulose and 0.1% polysorbate 80) in a limit test was performed using five male and five female rats. The rats were treated semi-occlusively for 24 hours and then observed for 14 consecutive days. No mortality occurred within the timeframe of the study. Clinical signs were limited to dyspnea, ruffled fur, and abnormal body positions, being common symptoms in acute tests. Additionally, diarrhea was observed on day 1 after application. All animals recovered within 13 days. Body weight gain was normal and no deviations from normal morphology were found at autopsy. Overall, under the chosen test conditions, the test substance does not have toxic properties in case of single dermal exposure: Dermal LD50 > 2000 mg/kg body weight.
Acute inhalation toxicity
No data available.
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
The available experimental test data is reliable and suitable for the purpose of classification under Directive 67/548/EEC. Based on the data, classification for acute toxicity is not warranted under Directive 67/548/EEC.
Classification, Labeling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are reliable and suitable for the purpose of classification under Regulation (EC) No.1272/2008. Based on the data, classification for acute toxicity is not warranted under Regulation (EC) No.1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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