Registration Dossier
Registration Dossier
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EC number: 453-480-2 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 October 2003 to 12 November 2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Deviations:
- not specified
- GLP compliance:
- yes
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Key result
- Type:
- log Pow
- Partition coefficient:
- >= 6.9
- Temp.:
- 20.4 °C
- Remarks on result:
- other: details on pH are not provided
- Details on results:
- The partition coefficient (n/octanol/water), Pow, calculated as a quotient of the n/octanol solubility and the water solubility of Hatcol 5127, was determined to be ≥ 7 .7x10^6 (log P ow ≥ 6.9) at 20.4 +/- 0.8°C.
- Conclusions:
- The partition coefficient (n-octanol/water), Pow, is calculated as a quotient of the n-octanol solubility and the water solubility of Hatcol 5127, was determined to be ≥ 7.7 x 10^6 (log Pow ≥ 6.9) at 20.4 +/- 0.8˚C
- Executive summary:
The determination of the partition coefficient (n-octanol/water) of Hatcol 5127 was based on the following guidelines:
Organization for Economic Co-operation and Development (OECD), OECD guidelines for testing of chemicals No :107."Partition coefficient (n-octanol/water): Shake Flask Method", Adopted July 27, 1995.
EEC directive 92/69 EEC, Part A, Methods for the determination of physlco-chemical properties, A.8: "Partition coefficient", EEC Publication on L383, December 1992.
The Estimation method was performed for the determination of the partition coefficient (n-octanol/water), Pow, of Hatcol 5127.
Estimation method
The n-octanol solubility of Hatcol 5127 was determined to be 1.1x10^3 g/l at 20.4 +/- 0.8°C
The water solubility of Hatcol 5127 at 20.4 +/-0.7°C is < 0.14x10-3 g/l (see NOTOX project 388035). The pH was measured to be 8.0 - 8.1.
The partition coefficient (n-octanol/water), Pow, calculated as a quotient of the n-octanol solubility and the water solubility of Hatcol 5127, is ≥ 7.7x10^6 (log Pow ≥ 6.9) at 20.4 +/-0.8°C.
Reference
Description of key information
The partition coefficient (n-octanol/water), Pow, is calculated as a quotient of the n-octanol solubility and the water solubility of Hatcol 5127, was determined to be ≥ 7.7 x 10^6 (log Pow ≥ 6.9) at 20.4 +/- 0.8˚C
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 6.9
- at the temperature of:
- 20.4 °C
Additional information
The determination of the partition coefficient (n-octanol/water) of Hatcol 5127 was based on the following guidelines:
Organization for Economic Co-operation and Development (OECD), OECD guidelines for testing of chemicals No :107."Partition coefficient (n-octanol/water): Shake Flask Method", Adopted July 27, 1995.
EEC directive 92/69 EEC, Part A, Methods for the determination of physlco-chemical properties, A.8: "Partition coefficient", EEC Publication on L383, December 1992.
The Estimation method was performed for the determination of the partition coefficient (n-octanol/water), Pow, of Hatcol 5127.
Estimation method
The n-octanol solubility of Hatcol 5127 was determined to be 1.1x10^3 g/l at 20.4 +/- 0.8°C
The water solubility of Hatcol 5127 at 20.4 +/-0.7°C is < 0.14x10-3 g/l (see NOTOX project 388035). The pH was measured to be 8.0 - 8.1.
The partition coefficient (n-octanol/water), Pow, calculated as a quotient of the n-octanol solubility and the water solubility of Hatcol 5127, is ≥ 7.7x10^6 (log Pow ≥ 6.9) at 20.4 +/-0.8°C.
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