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EC number: 266-045-5 | CAS number: 65997-16-2 High-Alumina cement is a mixture of chemical substances produced by burning or sintering at high temperature (greater than 1200°C (2192°F)) raw materials which are predominantly calcium carbonate, aluminium oxide, silica, and iron oxide. The chemical substances which are manufactured are confined in a crystalline mass. This category includes all of the chemical substances specified below when they are intentionally manufactured in the production of high-alumina cement. The primary members of this category are CaAl2O4, Ca4Al2Fe2O10, Ca12Al14O33, and Ca2SiO4. Other compounds listed below may also be included in the combination with these primary substances.@CaAl4O7@Ca2Al2SiO7@CaAl12O19@Ca4Al6SO16@Ca3Al2O6.@Ca12Al14Cl@CaO@Ca12Al14F2@Ca3SiO5@Ca6Al4Fe2.@Ca2Fe2O5.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010-01-22
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
- Type of study / information:
- Determination of the resorption in the digestive tract of CAHC according to DIN 19738 to determine the bioavailable parts.
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: DIN 19738
- Deviations:
- yes
- Remarks:
- Temperature in some conducts was outside the range of 37 ± 1 °C. As virtually no dissolution of the test item was observed, the deviation was assessed as uncritical; The samples were stored in closed vessels at 2 - 8°C; this is uncritical because met-als
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Cement, alumina, chemicals
- EC Number:
- 266-045-5
- EC Name:
- Cement, alumina, chemicals
- Cas Number:
- 65997-16-2
- Molecular formula:
- 3CaO.Al2O3.CaCO3.11H2O
- IUPAC Name:
- Cement, alumina, chemicals
Constituent 1
Results and discussion
Any other information on results incl. tables
Composition of Test Item
This was calculated from the data of X-ray analysis as presented in the following table:
Table9.1‑a Composition of Test Item
Parameter |
Mr in g/mol |
% in Oxide |
% in Test Item |
µg/g Test Item |
Al2O3 |
101.9613 |
- |
20.00% |
- |
Al |
26.9815 |
52.92% |
10.58% |
105849.9646 |
CaO |
56.08 |
|
41.00% |
- |
Ca |
40.08 |
71.74% |
29.30% |
293024.2511 |
Calculation of Mobilised Mass
The mobilised masses of the elements were calculated from
wi,mob = (ci * V)/mE with
wi,mob = mobilised part in µg/g test item per element
Ci = measured element concentration in µg/L
V = total volume in L of the aqueous phase (standard is 200 ml)
mE = weight of used test item (standard is 2.0 g)
Calculation of Bioaccessibility
Bioaccessibility was calculated from
Ri = (wi,mob * 100%)/wi,fest with
Ri = bioaccessible part in %
wi,mob = mobilised part in µg/g test item per element
wi,fest = part of the element in the test item in µg/g
Finding and Results
Two tests with and two tests without the addition of full milk powder were performed, as well as two blanks with and without milk powder.
An aliquot of the resulting solutions was thermically digested and resoluted in conc. HCl and water. The resulting solutions were measured via AAS for Al and Ca.
Al determinations were above LOQ.
The mobilised masses of the measured elements and the bioaccessibilities are given in tabular form.
Samples without addition of milk powder:
Measured Ingredient |
Parameter |
Mean |
Standard |
Relative Standard Deviation (%) |
Al |
Mobilised mass of test item in µg/g |
28.7803 |
23.8295 |
82.7980% |
Bioavailability in % |
0.0272% |
0.0002 |
82.7980% |
|
Ca |
Mobilised mass of test item in µg/g |
12327.8775 |
2376.2201 |
19.2752% |
Bioavailability in % |
4.2071% |
0.0081 |
19.2752% |
Samples with addition of milk powder:
Measured Ingredient |
Parameter |
Mean |
Standard |
Relative Standard Deviation (%) |
Al |
Mobilised mass of test item in µg/g |
9939.2498 |
7430.6891 |
74.7611% |
Bioavailability in % |
9.3900% |
0.0702 |
74.7611% |
|
Ca |
Mobilised mass of test item in µg/g |
7912.6201 |
10885.2337 |
137.5680% |
Bioavailability in % |
2.70% |
0.03715 |
137.5680% |
Applicant's summary and conclusion
- Conclusions:
- The Al components of the test item are very poorly soluble in the digestive tract. All values of the samples were above the values of the blanks and above LOQ, though.The Ca components of the test item are slightly soluble in the digestive tract. bioaccessibility was doubtlessl low and neither Ca nor Al are harmful in the concentrations which were found in the samples
- Executive summary:
The Al components of the test item are very poorly soluble in the digestive tract. All values of the samples were above the values of the blanks and above LOQ, though.The Ca components of the test item are slightly soluble in the digestive tract. bioaccessibility was doubtlessl low and neither Ca nor Al are harmful in the concentrations which were found in the samples
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