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EC number: 246-073-4 | CAS number: 24199-46-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study, most sensitive study available on this endpoint, but no GLP and no analytics were performed
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
- Reference Type:
- other: calculation
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: German standard DIN 38 412, Part 15
- GLP compliance:
- no
Test material
- Reference substance name:
- 6-methylhept-5-en-2-one
- EC Number:
- 203-816-7
- EC Name:
- 6-methylhept-5-en-2-one
- Cas Number:
- 110-93-0
- IUPAC Name:
- 6-methylhept-5-en-2-one
- Details on test material:
- - Name of test material (as cited in study report): Methylheptenon
- Lot/batch No.: 88/602
- Analytical purity: 98.2 %
- Physical state: liquid
water solubility: slightly soluble.
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: The test substance was added to the test water without any prior treatment.
Test organisms
- Test organisms (species):
- Leuciscus idus
- Details on test organisms:
- TEST ORGANISM
- Common name: Golden Orfe
- Length at study initiation (length definition, mean, range and SD): 6.0 cm (range: 5.5-7.1)
- Weight at study initiation (mean and range, SD): 1.8 g (range: 1.2-2.8)
- Feeding during test: 1 day before and during exposure
ACCLIMATION
- Acclimation period: 3 days
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 2.5 mmol/l
- Test temperature:
- 21+/-1°C
- pH:
- 7.5 - 7.9
- Dissolved oxygen:
- 7.5 - 8.7 mg/l
- Nominal and measured concentrations:
- Nominal test concentrations (mg/l):
46.6,
100,
215,
464,
1000,
control - Details on test conditions:
- TEST SYSTEM
- Test vessel: All-glass aquarium non-sealed (30 x 22 x 24 cm)
- Fill volume: 10 l
- Aeration: slight
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- Biomass loading rate: 1.8 g fish/l test water
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Dilution water chemistry: reconstituted freshwater was prepared from demineralized tap water that was resalted by the addition of 294.0 mg/l CaCl2*2H2O, 123.3 mg/l MgSO4*7H2O, 63.0 mg/l NaHCO3 and 5.5 mg/l KCl.
OTHER TEST CONDITIONS
- Photoperiod: 16:8 h day-night regime
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
Mortality and symptoms of intoxication
Results and discussion
Effect concentrations
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 50 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: effective concentration due to volatility
- Details on results:
- 96 h NOEC 46.4 mg/L (nominal) based on test material
96 h LC0 46.4 mg/L (nominal) based on test material
96 h LC100 100 mg/L (nominal) based on test material
In the control and up to nominal 46.4 mg test item/L, no fish died within 96 h of exposure and displayed no symptoms of intoxication. After 4 h, all fish died at nominal 100, 215, 464 and 1000 mg/l 6-methylhept-5-en-2-one. Thus, using the geometric mean of the LC0 of 46 mg/l and the LC100 of 100 mg/l a LC50 of 68.1 mg/l (geometric mean) could be calculated.
Due to a moderate volatility in an experiment using 100 mg and 200 mg of 6-methylhept-5-en-2-one, but without test organisms, the evaporation over 96 hours was observed. After 96 h approximately 23 % and 26 % of the test substance was evaporated (geometric mean of all measured TOC values between 0 h and 96 h), respectively. Therefore, the LC50(96h) can be corrected to be approximately 50 based on 26% evaporation. - Results with reference substance (positive control):
- The 48 h EC50 of the positive control (chloroacetamide) was 32 mg/l.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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