Registration Dossier
Registration Dossier
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EC number: 605-200-7 | CAS number: 160194-28-5
Endpoint summary
Administrative data
Description of key information
Additional information
In accordance with section 2 of Annex XI, the determination of the toxicity to aquatic invertebrates and aquatic algae is not feasible as the substance rapidly hydrolyzes and decomposes in water within the time frame required to perform these studies. These findings are based on results from the water solubility preliminary test (quantitative data) and
information supplied by the registrant. Basically the test substance would decompose within the time required to perform a main water solubility study (half-life < 12 hours). Therefore, a stable value for the water solubility for the test substance cannot be reached.
Therefore it is not technically possible to determine the acute toxicity to aquatic invertebrates or aquatic algae as the test substance will decompose rapidly in the test medium (water) for both aquatic studies. Strategies for modification to the aquatic study design were considered but were not deemed acceptable or viable options.
Assignment of Aquatic Chronic 4 classification was considered. Category chronic 4 can be triggered for poorly soluble substances where no acute toxicity is expressed in toxicity tests and where the log Kow ≥ 4 (indicating a bio-accumulating potential) and the substance is also not rapidly degradable. Thus, even though no acute toxicity has been measured in a short-term (acute) test for this test substance, the substance is rapidly degradable in water so an exposure period in the aquatic environment is not possible. Therefore, assignment of an Aquatic Chronic 4 classification is not warranted even though 'no acute toxicity' or water solubility value could be determined.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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