Dichloro(chloromethyl)methylsilane

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Well documented study. The deficiencies (mainly number of animals per dose) are scientifically and ethically accepatble due to the known corrosive properties of the substance.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1985

Report date:

1985

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

The purpose of this test was to determine an approximate lethal dose of chloro-methyl(dichloro)methylsilane, when administered as a single oral dose. The ALD was defined as the lowest dose administered which caused death either on the day of dosing or within 14 days post exposure. The technical procedure was comparable to OECD 401.

GLP compliance:

no

Test type:

fixed dose procedure

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Dichloro(chloromethyl)methylsilane

EC Number:

216-319-5

EC Name:

Dichloro(chloromethyl)methylsilane

Cas Number:

1558-33-4

Molecular formula:

C2H5Cl3Si

IUPAC Name:

dichloro(chloromethyl)methylsilane

Details on test material:

Purity 98%

Test animals

Species:

rat

Strain:

other: Crl:CD(SD)BR

Sex:

male

Details on test animals or test system and environmental conditions:

Male, 7-week old, Crl:CD(SD)BR rats were received from Charles River Breeding Laborato-ries, Kingston, NY. Rats were housed singly in suspended, stainless steel, wire-mesh cages. Each rat was assigned a unique identification number which was recorded on a card affixed to the cage. Purtna Certified Rodent Chow #5002 and water were available ad libi-tum. Rats were quarantined, weighed, and observed for general health for approximately one week prior to testing. Animal roams were maintained on a timer-controlled, 12 hour/12 hour light/dark cycle; temperatures ranged from 23-25°C and relative humidity from 38-63%.

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

corn oil

Details on oral exposure:

The test material was suspended in corn oil and administered to one rat per dose level by intragastric intubation. Dose levels administered ranged from 680 to 5,000 mg/kg in incre-ments of approximately 50%. The dosing day was considered to be day 1; post exposure day 14 was test day 15. Following administration of the dose rats were observed for clinical signs of toxicity. Surviving rats were weighed and observed daily until signs of toxicity sub-sided, and then at least every other day (weekends and holidays excluded) throughout the 14day recovery period.

Doses:

680, 990, 1500, 2200, 3400 and 5000 mg/kg bw

No. of animals per sex per dose:

1

Control animals:

no

Results and discussion

Effect levels

Effect levels 1

Sex:

male

Dose descriptor:

other: Mortality

Effect level:

680 mg/kg bw

Based on:

test mat.

Remarks on result:

other: Mortality: no

Effect levels 2

Sex:

male

Dose descriptor:

other: Mortality

Effect level:

990 mg/kg bw

Based on:

test mat.

Remarks on result:

other: Mortality: no

Effect levels 3

Sex:

male

Dose descriptor:

other: Mortality

Effect level:

1 500 mg/kg bw

Based on:

test mat.

Remarks on result:

other: Mortality: no

Effect levels 4

Sex:

male

Dose descriptor:

other: Mortality

Effect level:

2 200 mg/kg bw

Based on:

test mat.

Remarks on result:

other: Mortality: yes

Effect levels 5

Sex:

male

Dose descriptor:

other: Mortality

Effect level:

3 400 mg/kg bw

Based on:

test mat.

Remarks on result:

other: Mortality: yes

Effect levels 6

Sex:

male

Dose descriptor:

other: Mortality

Effect level:

5 000 mg/kg bw

Based on:

test mat.

Remarks on result:

other: Mortality: yes

Effect levels 7

Sex:

male

Dose descriptor:

other: ALD

Effect level:

> 1 500 - <= 2 200 mg/kg bw

Based on:

test mat.

Mortality:

yes, 2200 mg/kg bw and higher concentrations within 2 hours after administration.

Clinical signs:

other: Non lethal doses: Commonly observed clinical signs included lethargy, diarrhea, lung noise, wet perinea and limpness. Lethal doses: Commonly observed clinical signs included lethargy, lung noise, and sali-vation.

Applicant's summary and conclusion

Conclusions:

Although no guideline was followed and a LD50 cannot be derived the following can be concluded: Despite its corrosive properties Chloromethyl(dichloro)methylsilane is slightly toxic when administered in single oral doses to male rats. Based on the known local effects due to hydrochloric acid formation it can be concluded that the substance does not have a relevant potential for systemic toxicity.