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Diss Factsheets
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EC number: 202-874-0 | CAS number: 100-64-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented publication
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
- Principles of method if other than guideline:
- toxicokinetic study, no guideline available
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Cyclohexanone oxime
- EC Number:
- 202-874-0
- EC Name:
- Cyclohexanone oxime
- Cas Number:
- 100-64-1
- Molecular formula:
- C6H11NO
- IUPAC Name:
- cyclohexanone oxime
- Test material form:
- not specified
- Details on test material:
- Name of test material (as cited in study report): cyclohexanone oxime
- Analytical purity: unlabelled material from supplier recrystallised
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- [1-C14]-cyclohexanone oxime, specific activity 6.85 mCi per mmol
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- acetone
- Duration of exposure:
- 24 h
- Doses:
- 30 mg/kg bw
- No. of animals per group:
- 3
- Control animals:
- no
- Details on study design:
- Dermal exposure: The interscapular region was clipped 24 h before exposure. The animals were anesthesised with ketamine and 30 mg/kg bw were applied at 0.2 mL/kg bw in a circular area of 1 cm2. The application site was covered with a perforated metal tissue capsule, glued directly to the skin. The aminals were kept individually in metabolism cages and sacrificed 24 h after exposure.
Results and discussion
- Signs and symptoms of toxicity:
- not specified
- Dermal irritation:
- not specified
- Absorption in different matrices:
- - Skin test site: 4.52 % of adminstered dose remaining after 24 h
- Blood: 0.053 %
- Carcass: tissues: 0.408 %; liver: 0.036 %; kidney: 0.007 %; skin: 0.099 %; muscle: 0.036 %; small intestine: 0.007 %; small intestine content: 0.026 %; large intestine: 0.006 %; large intestine content: 0.046 %
- Urine: 3.86 %
- Faeces: 0.089 %
- Volatiles: 22.6 % - Total recovery:
- - Total recovery: 31.4 %
Percutaneous absorption
- Dose:
- 30 mg/kg bw
- Parameter:
- percentage
- Absorption:
- ca. 5 %
- Remarks on result:
- other: 24 h
Any other information on results incl. tables
Distribution and elimination after dermal application were not different from those observed after oral administration.
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of this study the systemic absorption after dermal expposure was approx. 5%
- Executive summary:
Three male rats were exposed dermally to 30 mg/kg bw. Within 24 h after exposure start, 3.9% was excreted in urine and 0.1% in feces, 4.5% remained at the application site and 23% had volatilised within 3 -5 min after application. Therefore the systemic uptake after dermal exposure is in the range of 5% of the administered dose.
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