Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 247-501-2 | CAS number: 26175-68-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1982
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well performed GLP and OECD guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD guideline for testing of chemicals; section 4: Health Effects; Acute oral Toxicity; Adopted May 12, 1981
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 4-amino-2,5-dichloro-N,N-dimethylbenzenesulphonamide
- EC Number:
- 247-501-2
- EC Name:
- 4-amino-2,5-dichloro-N,N-dimethylbenzenesulphonamide
- Cas Number:
- 26175-68-8
- Molecular formula:
- C8H10Cl2N2O2S
- IUPAC Name:
- 4-amino-2,5-dichloro-N,N-dimethylbenzene-1-sulfonamide
- Details on test material:
- - Name of test material (as cited in study report): 1-Amino-2,5-dichlorbenzol-4-sulfonsaeure-dimethylamid (ADCS)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Kleintierfarm Madoerin AG, 4414 Fuellinsdorf/Switzerland
- Age at study initiation: approximately 9 weeks
- Weight at study initiation: males: 151 - 194 g; females 150 - 176 g
- Housing: Groups of five animals in Macrolone cages Type 3 with wire mash tops
- Diet: Pelleted standard Kliba 24/343/1 rat maintenance diet ad libitum
- Water : tap water ad libitum
- Acclimation period: 1 week under test conditions
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +-2
- Humidity (%): 55 +-10
- Air changes (per hr):
- Photoperiod: Light Cycle 12 hours/day
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Remarks:
- 2% solution in dist water
- Doses:
- group 1: 1000 mg/kg bw
group 2: 3000 mg/kg bw
group 3: 5000 mg/kg bw - No. of animals per sex per dose:
- 5 males and 5 femals per dose group
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily for specified symptomes and mortality, bodyweights were recorded at day 1, 7, 14
- Necropsy of survivors and animals found dead performed: yes
- Other examinations performed: clinical signs, body weight, autopsy and macroscopical examination - Statistics:
- Logit Estimation
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 4 087 mg/kg bw
- Based on:
- test mat.
- Mortality:
- group 1 (1000 mg/kg bw): 0/5 males, 0/5 females
group 2 (3000 mg/kg bw): 1/5 males, 1/5 females
group 3 (5000 mg/kg bw): 2/5 males, 5/5 females - Clinical signs:
- other: 1000 MG/KG: SEDATION, DYSPNOEA, EXOPHTHALMOS, VENTRAL- OR CURVED BODY POSITION, RUFFLED FUR 3000 MG/KG: SEDATION, COMA, DYSPNOEA, ATAXIA, VENTRAL-, LATERO-ABDOMINAL-, OR CURVED BODY POSITION, RUFFLED FUR 5000 MG/KG: SEDATION, SOMNOLENCE, COMA, DYSPNO
- Gross pathology:
- NO MACROSCOPICAL ORGAN CHANGES WERE OBSERVED.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- LD50 male and female: 4087 mg/kg bw
- Executive summary:
The test substance was abministered orally to rats of both sexes in doses of 1000, 3000 and 5000 mg(kg bw. The death rates were 0% at 1000 mg/kg bw, 20% at 3000 mg/kg bw and 70% at 5000 mg/kg bw. Based on these observations the LOGIT-ESTIMATION for the acute oral LD50 in rats of both sexes is 4087 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.