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Diss Factsheets
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EC number: 700-880-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2011
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Distillate of aerobic enzymatic oxidation products of patchouli oil alpha-guaiene rich fraction
- EC Number:
- 700-880-2
- IUPAC Name:
- Distillate of aerobic enzymatic oxidation products of patchouli oil alpha-guaiene rich fraction
Constituent 1
Test system
- Amount / concentration applied:
- Each 0.75 mL of the undiluted test item were applied to three bovine corneas.
- Duration of treatment / exposure:
- The corneas were exposed to the undiluted test item for 10 minutes.
- Details on study design:
- Three corneas were exposed to each 0.75 mL of the neat item to 10 minutes. After the treatment the test item was rinsed off the corneas and they were incubated for further 2 hours. After the 2 hours incubation the corneas' opacity was determined. In a second step the permeability of the corneas was determined. In a second step the permeability of the corneas was determined photometrically after 90 minutes treatment with fluorescen solution.
Results and discussion
In vivo
- Irritant / corrosive response data:
- Relative to the negative control, the test item Akigalawood did not cause any opacity or permeability of the corneae. The calculated mean in vitro score was 0.00. In conclusion, according to the current study and under the experimental conditions reported, the test item Akigalawood is not corrosive to the eye (CLP/EPA/GHS).
Any other information on results incl. tables
In vitro test
Applicant's summary and conclusion
- Interpretation of results:
- other: not corrosive
- Remarks:
- Criteria used for interpretation of results: OECD GHS
- Conclusions:
- In conclusion, it can be stated that in this study and under the experimental conditions reported, according to the CLP/EPA/GHS classification the test itema Akigalawood is not considered to be corrosive to the eye. According to the INVITTOX (UK) protocol No. 98 the test item is classified as non eye irritant.
- Executive summary:
The test item was tested undiluted. The positive control 2 -Ethoxyethanol was tested neat. Saline was used as negative control item.
After a first opacity measurement of the fresh bovine coreneae (t0), the neat test item Akigalawood, the positive, and the negative controls were applied to the corneae and incubated for 10 minutes at 32 ± 1°C in complete medium. After the incuvbation phase the test item, the positive and the negative controls were each rinsed from the corneae. Further, the corneae were incubated for another 120 minutes at 32 ± 1°C in completed medium, and opacity was measured a second time ( t130).
After the opacity measurements permeability of the corneae was determined by measuring spectrophotometrically the transfer of fluorescein after incubation in a horizontal position for 90 minutes at 32± 1°C.
With the negative control (saline) neither an increase of opacity and distinctive permeability of the corneae (mean in vitro score 69.29) corresponding to a classification as corrosive to the eye (CLP/EPA/GHS (classI)).
Relative to the negative control, the test item Akigalawood did not cause an increase of the corneal opacity and permeability. The calculated mean in vitro score was 0.00.
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