2-methylhydroquinone

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Scientifically acceptable publication; although the exposure period was reduced to 24 h, sufficient data was given in the publication on testing procedure to justify the study as val2 for the endpoint short-term toxicity to aquatic invertebrates.

Data source

Reference

Reference Type:

publication

Title:

Biological effects of prenylated hydroquinones: structure-activity relationship studies in antimicrobial, brine shrimp, and fish lethality assays

Author:

De Rosa, S., De Giulio, A. and Iodice, C.

Year:

1994

Bibliographic source:

Journal of Natural Products, Vol. 57, No. 12, pp. 1711-1716

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

A test guideline was not mentioned in the publication.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-methylhydroquinone

EC Number:

202-443-7

EC Name:

2-methylhydroquinone

Cas Number:

95-71-6

Molecular formula:

C7H8O2

IUPAC Name:

2-methylbenzene-1,4-diol

Constituent 2

Reference substance name:

Methylhydroquinone

IUPAC Name:

Methylhydroquinone

Details on test material:

- Origin of test material: Sigma-Aldrich s.r.l., Italy

Sampling and analysis

Analytical monitoring:

no

Test solutions

Vehicle:

yes

Details on test solutions:

PREPARATION OF TEST SOLUTION
- Test item was dissolved in DMSO (1% final volume)

Test organisms

Test organisms (species):

Artemia salina

Details on test organisms:

- Organism: Brine Shrimp (freshly hatched larvae)

Study design

Test type:

static

Water media type:

saltwater

Limit test:

no

Total exposure duration:

24 h

Test conditions

Nominal and measured concentrations:

- Concentrations tested (nominal): 10, 0.1 and 0.01 ppm

Details on test conditions:

TEST SYSTEM
- No. of replicates/concentration: 3
- No. of organisms/replicate: 10
- Introduction of organism to test medium: freshly hatched larvae were placed in 5 mL artificial sea water to which appropriate amounts of compound (dissolved in DMSO) were added.

Results and discussion

Effect concentrations

Duration:

24 h

Dose descriptor:

LC50

Effect conc.:

> 10 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality

Reported statistics and error estimates:

The data was statistically analyzed by the Finney program.