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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2011
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data from peer-reviewed hadbook or collection of data. Reliable source (GESTIS)

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2009

Materials and methods

Principles of method if other than guideline:
According to Annex VII "Standard Information Requirements for Substances Manufactured or Imported in Quantities of one Tonne or More" of the "Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC” (as amended) (OJ L 396, 30.12.2006, p 1), 8.5, a study on acute toxicity is required under certain conditions. However, as the substance is classified and the acute toxicity an be assessed, (animal) testing is not required
GLP compliance:
not specified
Test type:
other: Assessment and expert judgement
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,3-propanesultone
EC Number:
214-317-9
EC Name:
1,3-propanesultone
Cas Number:
1120-71-4
Molecular formula:
C3H6O3S
IUPAC Name:
1,2-oxathiolane 2,2-dioxide
Details on test material:
Quelle : 02071
Toxicological Data, compiled by the National Institute of Health (NIH), USA, selected and distributed by Technical Database Services (TDS), New York, 2009
no other information available in the GESTIS: http://biade.itrust.de/biade/lpext.dll/Infobase/uberschrift43397?f=templates&fn=main-h.htm&2.0

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
not reported
Doses:
no information available
No. of animals per sex per dose:
no information available
Control animals:
not specified
Details on study design:
no information available
Statistics:
no information available

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
100 mg/kg bw
Based on:
test mat.
Remarks on result:
other: limited data base

Any other information on results incl. tables

Acute oral data retrieved from GESTIS (Gefahrstoff-Informations-System der Berufsgenossenschaften http://gestis.itrust.de)

Institut für Arbeitsschutz der Deutschen Gesetzlichen Unfallversicherung (IFA)
Division 1
Alte Heerstr. 111
53757 Sankt Augustin
Germany

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
LD50 oral rat 100 mg/kg