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Diss Factsheets
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EC number: 941-814-4 | CAS number: 157367-45-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- December 1991 to January 1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted according to OECD guideline under GLP
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- Principles of method if other than guideline:
- not relevant
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 308 AQN
- IUPAC Name:
- 308 AQN
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- One new Zealand White rabbit was supplied by David Percival Ltd., Moston, sandbach, Cheshire, U.K. At the start of the study the animal weighed 2.26 kg and was approximately twelve to sixteen weeks old. After a minimum acclimatisation period of five days the animal was given a number unique within the study which was written with a black indelible marker-pen on the inner surface of the ear and on a cage label.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.1ml = 65 mg
- Duration of treatment / exposure:
- The upper and the lower eyelids were held together for about one second.
- Observation period (in vivo):
- 1 hour, 24 and 48 hours
- Number of animals or in vitro replicates:
- 1
- Details on study design:
- TOOL USED TO ASSESS SCORE: fluorescein
Results and discussion
In vivo
Results
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- animal #1
- Time point:
- other: 48h
- Score:
- 81
- Reversibility:
- not specified
- Irritant / corrosive response data:
- A dulling of the normal lustre of the corneal surface was noted in the treated eye one hour after treatment. Opalescent corneal opacity was noted in the treated eye at the 24-hour observation, with areas of opaque corneal opacity at the 48-hour observation. Corneal opacity was confirmed using sodium fluorescein B.P. in the treated eye one hour after treatment and at the 24 and 48-hour observations.
Iridial inflammation was noted in the treated eye one hour after treatment and at the 24 and 48-hour observations.
Moderate conjunctival irritation was noted in the treated eye one hour after treatment with severe conjunctival irritation at the 24 and 48-hour observations. A Pale appearance of the nictitating membrane was also noted at the 48-hour observation.
Any other information on results incl. tables
A dulling of the normal lustre of the corneal surface was noted in the treated eye one hour after treatment. Opalescent corneal opacity was noted in the treated eye at the 24-hour observation, with areas of opaque corneal opacity at the 48-hour observation. Corneal opacity was confirmed using sodium fluorescein B.P. in the treated eye one hour after treatment and at the 24 and 48-hour observations.
Iridial inflammation was noted in the treated eye one hour after treatment and at the 24 and 48-hour observations.
Moderate conjunctival irritation was noted in the treated eye one hour after treatment with severe conjunctival irritation at the 24 and 48-hour observations. A Pale appearance of the nictitating membrane was also noted at the 48-hour observation.
Applicant's summary and conclusion
- Interpretation of results:
- highly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: other: Modified Kay and Calandra Interpretation of Eye Irritation Test
- Conclusions:
- The test material, No. 308 AQN, produced a maximum total score of 81 and was considered to be at least a very severe irritant (class 7 on a 1 to 8 scale) to the rabbit eye according to a modified Kay and Calandra classification system (based on one rabbit only).
- Executive summary:
The test material, No. 308 AQN, produced a maximum total score of 81 and was considered to be at least a very severe irritant (class 7 on a 1 to 8 scale) to the rabbit eye according to a modified Kay and Calandra classification system (based on one rabbit only).
It is also reasonable to assume the symbol "Xi" and at least the risk phrase R 35 "Irritation to Eyes" according to EEC labeling regulations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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