Registration Dossier
Registration Dossier
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EC number: 806-533-2 | CAS number: 1219086-87-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 October - 10 December 2015
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- (2Z)-3-(3-chloro-2-fluorophenyl)-2-(4-chloro-2-fluorophenyl)prop-2-enenitrile
- EC Number:
- 806-533-2
- Cas Number:
- 1219086-87-9
- Molecular formula:
- C15 H7 Cl2 F2 N
- IUPAC Name:
- (2Z)-3-(3-chloro-2-fluorophenyl)-2-(4-chloro-2-fluorophenyl)prop-2-enenitrile
- Test material form:
- other: white solid
- Details on test material:
- IUPAC Name : (Z)-3-(3-chloro-2-fluorophenyl)-2-(4-chloro-2-fluorophenyl)-acrylonitrile
Roche number : RO5463921-000
Formula : C15H7Cl2F2N
Molecular weight : 310,13 g/mol
Batch : FIS201405080058
Purity : 101,2 % (m/m)
Expiry date : 11 June 2016
Storage conditions : room temperature in the dark under nitrogen
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- arachis oil
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5 animals per dose
- Control animals:
- no
Results and discussion
Any other information on results incl. tables
A single animal was treated at 2000 mg/kg. In the absence of mortality at a dose of 2000 mg/kg, an additional group of 4 animals was treated at 2000 mg/kg.
There were no deaths.
No signs of systemic toxicity were noted during the observation period.
All animals showed expected gains in body weight over the observation period.
No abnormalities were noted at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: CLP
- Conclusions:
- The acute oral median dose LD50 of PAC-Ethenenitrile (CAS Nr 1219086-87-9) in the female Wistar strain rat was estimated to be greater than 2000 mg/kg body weight.
- Executive summary:
The acute oral median dose LD50 of PAC-Ethenenitrile (CAS Nr 1219086-87-9) in the female Wistar strain rat was estimated to be greater than 2000 mg/kg body weight (Globally Harmonized Classification System : unclassified).
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