Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
ACUTE ORAL TOXICITY OF P-TERT-BUTYLBENZOIC ACID IN RATS
Year:
1987
Bibliographic source:
Source: EPA/OTS

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
EPA OPPTS 870.1100 (Acute Oral Toxicity)
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Wistar
Sex:
female
Details on test animals and environmental conditions:
Acute oral toxicity was evaluated in groups of 10 female SPF Wistar rats administered single doses of P-tert-butylbenzoic acid using a probang (a flexible rod with a tuft or sponge at the end, used to apply to or remove matter from the esophagus or larynx)

Administration / exposure

Route of administration:
oral: gavage
Doses:
at levels of 400, 500, 630, 800, 1000, and 1600 mg/kg of body weight

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
ca. 642 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information