Boronic acid, B-(6-hydroxy-2-naphthalenyl)-

Particle size distribution (Granulometry)

Administrative data

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

21 October 2013 to 13 December 2013

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: non GLP.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2013

Report date:

2014

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: European Commission Technical Guidance Document EUR 20268 'Determination of Particle Size Distribution, Fibre Length and Diameter Distribution of Chemical Substances' (2002)

GLP compliance:

yes

Remarks:

OECD Principles on Good Laboratory Practice (revised 1997, ENV/MC/CHEM(98)17)

Type of distribution:

mass based distribution

Test material

Test material information

Constituent 1

Reference substance name:

(6-hydroxynaphthalen-2-yl)boronic acid

EC Number:

687-349-8

Cas Number:

173194-95-1

Molecular formula:

C10H9BO3

IUPAC Name:

(6-hydroxynaphthalen-2-yl)boronic acid

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Results and discussion

Particle size

Percentile:

D50

Remarks on result:

other: Migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.

Particle size distribution at different passages

Particle size distribution at different passages 1

Size:

< 100 µm

Distribution:

98.5 %

Particle size distribution at different passages 2

Size:

< 10 µm

Distribution:

5.67 %

Particle size distribution at different passages 3

Size:

< 5.5 µm

Distribution:

2.51 %

Any other information on results incl. tables

Using the data obtained from the cascade impactor method determinations, the cumulative mass and cumulative percentage are calculated as follows:

Collection Stage	Particle Size Range Collected (µm)	Mass at Stage (g)	Cumulative Mass (g)	Cumulative Percentage (%)
Artificial Throat	-	mo	Mo	100
Sample Cup 1	>10.0	m1	M1	100 x M1/Mo
Sample Cup 2	5.5 to 10.0	m2	M2	100 x M2/Mo
Sample Cup 3	2.4 to 5.5	m3	M3	l00 x M3/Mo
Sample Cup 4	1.61 to 2.4	m4	M4	100 x M4/Mo
Sample Cup 5	0.307 to 1.61	ms	Ms	100 x M5/Mo
Final Filter	<0.307	m6	M6	100 x M6/Mo

Where:

m = mass of test item (g) found at collection stage.

M  = cumulative mass (g) from collection stage on (eg M3=m3 + m4 +m5 +m6)

Applicant's summary and conclusion

Conclusions:

98.5% of particles were <100um.
5.67% of particles were <10.0um.
2.51% of particles were <5.5um

Executive summary:

Too few particles were of a size less than 10.0µm to allow accurate assessment of the mass median aerodynamic diameter.

Sampling for the cascade impactor determinations was performed by rolling the test item container for approximately 15 minutes then sampled from the top, middle and bottom.