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Diss Factsheets
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EC number: 203-252-1 | CAS number: 104-92-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- At the time of the study no GLP-rules had been established; therefore the study is a non-GLP study. A modification of Ames test was used and a detailled documentation of testing procedure is given. The testing procedure was similar to OECD guideline 471; positive and negative controls were included; 10 tester strains including the ones recommended by OECD 471, were used in the test; no definite exposure concentrations were tested, but a concentration-gradient; no data on analytical results of the test substance, no individual data and no data on the storage of the individual values are given. The reputation of the test laboratory allows to speculate that these data exist and have been stored.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Principles of method if other than guideline:
- Screening is done using a concentration gradient of the test substance and 10 tester strains on one Agar plate, 8 Agar plates were prepared for each substance: with concentration gradients approx. 0.1-1, 1-10, 10-100 and 100 to 1000 µg/ml and with and without metabolic activation; hence, no definite concentrations were tested; as result the upper and lower concentrations tested or those with a positive result are reported.
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- p-Bromoanisole
- IUPAC Name:
- p-Bromoanisole
- Test material form:
- not specified
- Details on test material:
- no furter data given
Constituent 1
Method
- Target gene:
- - Dependant on the strain tested; histidine in many cases
Species / strainopen allclose all
- Species / strain / cell type:
- E. coli, other: WP2 tryptophan
- Species / strain / cell type:
- E. coli WP2 uvr A
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Species / strain / cell type:
- S. typhimurium, other: G46, C3076, D3052 and TA1538
- Metabolic activation:
- with and without
- Metabolic activation system:
- mixture of rat liver enzymes from animals treated with Aroclor
- Test concentrations with justification for top dose:
- - No distinct concentration tested, but testing of four concentration gradients: approx. 0.1-1, 1-10, 10-100 and 100 to 1000 µg/ml
- Vehicle / solvent:
- dimethyl sulfoxide, water or dimethoxyethane
Controls
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- not specified
- True negative controls:
- not specified
- Positive controls:
- yes
- Positive control substance:
- 2-acetylaminofluorene
- other: streptozotocin
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: in agar (plate incorporation)
DURATION
Exposure duration:48 hr
DETERMINATION OF CYTOTOXICITY
yes - Evaluation criteria:
- - The concentration range over which chemically induced mutant colonies are present is recorded
- Statistics:
- - Operator judgement
- Experienced personel
Results and discussion
Test results
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Additional information on results:
- The single values of the testing results are missing. The result "negative" is only listed in a table(no. 6).
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
According to the authors of the study, a negative result was obtained for p-Bromoanisole in the concentation range of 0.1 to 1000 µg/mL with and without metabolic activation. - Executive summary:
The mutagenic potential of para bromoanisole was tested in vitro in a bacterial reverse mutation assay. The test was performed similar to the OECD guideline 417 (Ames test), but a modification was used. 10 tester strains, including the ones recommended in the OECD 417 guideline, were tested. However, instead of definite concentrations, concentration ranges (0.1 - 1, 1 - 10, 10 - 100 and 100 - 1000 µg/ml) of the test substance were tested. Positive and negative controls were included and the test was performed with and without metabolic activation. About 854 chemicals next to para bromoanisole were tested in the same study. According to the authors of the study, p-Bromoanisole showed no mutagenic potential in the concentation range of 0.1 to 1000 µg/mL with and without metabolic activation. The study was considered to be reliable with restrictions.
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