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EC number: 919-846-5 | CAS number: 1187203-83-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
No experimental toxicokinetic study is available on 4,4'-lsopropylidenediphenol, ethoxylated, esters with acrylic acid and isononanoic acid. However, as per REACH guidance document R7.C (May 2008), information on absorption, distribution, metabolisation and excretion may be deduced from the physicochemical properties.
Based on the toxicological data and the physicochemical properties, the absorption of 4,4'-lsopropylidenediphenol, ethoxylated, esters with acrylic acid and isononanoic acid is expected to be possible by oral route, dermal route and inhalation.
Key value for chemical safety assessment
Additional information
No experimental toxicokinetic study is available on 4,4'-lsopropylidenediphenol, ethoxylated, esters with acrylic acid and isononanoic acid. However, as per REACH guidance document R7.C (May 2008), information on absorption, distribution, metabolisation and excretion may be deduced from the physico-chemical properties, including:
-Mean molecular weight: Mean 414 g/mol, range [316;795] with 85.5% < 500 g/mol
-Water solubility: 16.39 mg/L (20°C) (slightly soluble)
-Partition coefficient Log Kow: between 1.49 -4.74 (83% of the substance)
-Vapour pressure: 0.00000417 Pa (25 °C)
ABSORPTION
The low solubility of 4,4'-lsopropylidenediphenol, ethoxylated, esters with acrylic acid and isononanoic acid is favorable for a low oral absorption. With a moderate value of Log Kow [1,49 ; 4,74], the compound could be absorbed by oral route.
No clinical effects were observed after one single (2000 mg/kg) of 4,4'-lsopropylidenediphenol, ethoxylated, esters with acrylic acid and isononanoic acid by gavage (oral route) in rats. An oral absorption is expected to be possible for 4,4'-lsopropylidenediphenol, ethoxylated, esters with acrylic acid and isononanoic acid.
With a solubility of 16.39 mg/L, dermal absorption is anticipated to be low. However, the moderate value of Log Kow and the molecular mass below 500 g/mol are favourable to a dermal absorption. The acrylates are known to bind to skin components, and this binding decreases their dermal absorption. Indeed, the dermal absorption of 4,4'-lsopropylidenediphenol, ethoxylated, esters with acrylic acid and isononanoic acid is anticipated to be possible. In the dermal acute toxicity study, where no systemic effect or mortality were observed in rats treated with 2000 mg/kg bw. However, 4,4'-lsopropylidenediphenol, ethoxylated, esters with acrylic acid and isononanoic acid showed allergic reaction in the LLNA: it is evidence that some uptake must have occurred although it may only have been a small fraction of the applied dose.
Based on the low value of the vapour pressure (<0.1 Pa), 4,4'-lsopropylidenediphenol, ethoxylated, esters with acrylic acid and isononanoic acid is not a volatile substance. Moreover, the absorption by inhalation can be expected to be low for
4,4'-lsopropylidenediphenol, ethoxylated, esters with acrylic acid and isononanoic acid based on the values of water solubility and log kow.
DISTRIBUTION and METABOLISM
No specific data is available on the distribution or metabolism of 4,4'-lsopropylidenediphenol, ethoxylated, esters with acrylic acid and isononanoic acid.
In the 28 -day and 90 -day repeated toxicity studies, some effects on organs were observed suggesting a good distribution into the organism.
ELIMINATION
Due to the low water solubility and the moderate molecular mass, the excretion of 4,4'-lsopropylidenediphenol, ethoxylated, esters with acrylic acid and isononanoic acid in the urines is expected to be low. An excretion via bile and faeces is possible.
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