1,6-hexanediyl-bis(2-(2-(1-ethylpentyl)-3-oxazolidinyl)ethyl)carbamate

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The data are available from ECHA as data older than 12 years of age and no longer protected. The registrant has been unable to varify the quality of the original data

Data source

Reference

Reference Type:

other company data

Title:

Unnamed

Year:

1993

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

1,6-hexanediyl-bis(2-(2-(1-ethylpentyl)-3-oxazolidinyl)ethyl)carbamate

EC Number:

411-700-4

EC Name:

1,6-hexanediyl-bis(2-(2-(1-ethylpentyl)-3-oxazolidinyl)ethyl)carbamate

Cas Number:

140921-24-0

Molecular formula:

C32H62N4O6

IUPAC Name:

2-[3-(heptan-3-yl)-1,2-oxazolidin-2-yl]ethyl N-{6-[({2-[3-(heptan-3-yl)-1,2-oxazolidin-2-yl]ethoxy}carbonyl)amino]hexyl}carbamate

Test animals / tissue source

Species:

rabbit

Strain:

New Zealand White

Test system

Vehicle:

unchanged (no vehicle)

Controls:

not specified

Duration of treatment / exposure:

Unwashed

Observation period (in vivo):

24, 48 and 72h

Number of animals or in vitro replicates:

3

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

other: 24h

Score:

0

Max. score:

0

Reversibility:

fully reversible

Results 2

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

other: 48h

Score:

0

Max. score:

0

Reversibility:

fully reversible

Results 3

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

other: 72h

Score:

0

Max. score:

0

Reversibility:

fully reversible

Any other information on results incl. tables

Irritation parameter	Basis	Time point	Score	Max.score	Reversibility	Remarks
conjunctivae score (redness)	animal #1 (mean score 1)	overall at 24, 48 and 72 h	0
conjunctivae score (redness)	animal #2 (mean score 2)	overall at 24, 48 and 72 h	0
conjunctivae score (redness)	animal #3 (mean score 3)	overall at 24, 48 and 72 h	0
conjunctivae score (redness)				0		Max. duration: 0 h; Max. value at end of observation period: 0 (related to all animals)
chemosis score	animal #1 (mean score 1)	overall at 24, 48 and 72 h	0
chemosis score	animal #2 (mean score 2)	overall at 24, 48 and 72 h	0
chemosis score	animal #3 (mean score 3)	overall at 24, 48 and 72 h	0
chemosis score				0		Max. duration: 0 h; Max. value at end of observation period: 0 (related to all animals)
cornea score	animal #1 (mean score 1)	overall at 24, 48 and 72 h	0
cornea score	animal #2 (mean score 2)	overall at 24, 48 and 72 h	0
cornea score	animal #3 (mean score 3)	overall at 24, 48 and 72 h	0
cornea score				0		Max. duration: 0 h; Max. value at end of observation period: 0 (related to all animals)
iris score	animal #1 (mean score 1)	overall at 24, 48 and 72 h	0
iris score	animal#2 (mean score 2)	overall at 24, 48 and 72 h	0
iris score	animal #3 (mean score 3)	overall at 24, 48 and 72 h	0
iris score				0		Max. duration: 0 h; Max. value at end of observation period: 0 (related to all animals)

Applicant's summary and conclusion

Interpretation of results:

not irritating

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The substance is not irritating to eyes.

Executive summary:

The test substance has been assessed for irritation to the eyes of New Zealand White rabbits by exposure unchanged. No adverse reactions have occured and the substance is considered to be not irritating to eyes.