Registration Dossier
Registration Dossier
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EC number: 205-500-4 | CAS number: 141-78-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study report with basic details reported but sufficient to judge as meeting basic scientific priniciples and therefore reliable for with restrictions.
Data source
Reference
- Reference Type:
- publication
- Title:
- Range finding toxicity data: List VI
- Author:
- Smyth HF, Carpenter CP, Weil CS, Pozzani UC, Striegel BS
- Year:
- 1 962
- Bibliographic source:
- Am Ind Hyg Ass J, 23, 95
Materials and methods
- Principles of method if other than guideline:
- Follows basic principles of an OECD401 but there is insufficient information to rank it as 'equivalent or similar'. A number of the observations normally now required are not reported.
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Ethyl acetate
- EC Number:
- 205-500-4
- EC Name:
- Ethyl acetate
- Cas Number:
- 141-78-6
- Molecular formula:
- C4H8O2
- IUPAC Name:
- ethyl acetate
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Own colony
- Age at study initiation: 4-5 weeks
- Weight at study initiation: 90-120g
- Diet : Rockland rat diet
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: see other information.
- Doses:
- Not specified. Doses were arranged in a logarithmic series with a factor of 2 between doses.
- No. of animals per sex per dose:
- 5
- Control animals:
- other: A number of other substances were also tested in the same study
- Details on study design:
- Duration of observation period following administration: 14 days
- Statistics:
- LD50 value and precision estimated by method of Thompson (Bacteriol Rev, 11, 115, 1947) and tables of Weil (Biometrics, 8, 249 ,1952)
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 11.3 mL/kg bw
- Remarks on result:
- other: no data on confidence limits. LD50 is equivalent to 10,200mg/kg
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Substance of low toxicity by the oral route.
- Executive summary:
In an old study report where basic but sufficient experimental details were reported, an LD50 of 10200mg/kg was established in female rats.
Synopsis
LD50 (male rats) = 10,200mg/kg
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