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EC number: 915-206-4 | CAS number: -
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Climie IJG (1979). Metabolism studies on a mixture of 9-eicosyl-9-phosphabicyclo-[421] and [331] nonanes (RM-17) in the rat: (1) Fate of a single oral dose of [14C] RM-17. Shell Toxicology Laboratory, Report. TLGR. 79.052
The objective of the study was to determine the distribution and elimination of RM-17 following a single oral dose to rats.
Six female rats were each given a single oral dose of [14C] RM-17 (25.4 mg, approximately 12 mg.kg-1). Urine and faeces were monitored daily for radio activity. The animals were sacrificed in groups of two at one, three and eight days after administration of the compounds and samples of their intestine, skin, liver, kidney, brain and carcass were assayed for radioactivity. Fat, muscle and blood samples were also radioassayed.
Excretion of the compound was found to be rapid. 93% of the administered dose was eliminated within three days: 67% of the dose in the faeces and 26% in the urine. Only 0.4% of the dose remained in the animals after eight days. The mean percentage recovery of the radioactivity was 94%
Climie IJG (1979). Metabolism studies on a mixture of 9-eicosyl-9-phosphabicyclo-[421] and [331] nonanes (RM-17) in the rat: (2) Fate of a single dermal application of [14C] RM-17. Shell Toxicology Laboratory, Report. TLGR. 79.078
The objective of the study was to determine the distribution and elimination of RM-17 following a single dermal application to rats.
Three female rats were each given a single dermal application of [14C] RM-17 (0.5 mg, approximately 2. mg.kg-1) applied as an acetone solution. Urine and faeces were monitored daily for radioactivity. The animals were sacrificed five days after application of the compound and samples of their intestine, skin, liver, kidney and remaining carcass were assayed for radioactivity. Fat and blood samples were also radioassayed.
The percutaenous absorption of RM-17 was very low. The majority of the radioactivity was recovered from the skin and from the aluminium foil and sealing tape covering the application area. After 5 days the average total elimination of radioactivity in urine and faeces was 0.8% and 0.6% of the applied dose respectively. Only 0.1% of the applied dose remained in the animals after 5 days (excluding skin).
Climie IJG (1979). Metabolism studies on a mixture of 9-eicosyl-9-phosphabicyclo-[421] and [331] nonanes (RM-17) in the rat: (3) Nature of the metabolites in urine and faeces after a single oral dose of [14C] RM-17. Shell Toxicology Laboratory, Report. TLGR. 79.039
The objective of the study was to characterise and quantify the metabolites of RM-17 in urine and faeces.
The metabolites of TM-17 in the urine and faeces were separated by chromatographic techniques. The major metabolites were isolated and quantified by physicochemical techniques.
The major metabolite of RM-17 was excreted in the faeces and was identified as RM-17 oxide. The major urinary metabolite (18% of dose in tow days) was partially identified as ω-carboxylic acid although its full structure was not determined.
Baldwin MK & DG Clark (1980); The toxicology of catalysts: Dermal decontamination studies with RM-17, Shell Toxicology Laboratory, Report TLGR. 80.005
A study was performed in order to develop an effective technique for removing RM-17 from the skin
Molten (50°C) RM-17 was applied to rabbit skin and removed 15 minutes later by scraping with a spatula, or by vigorously swabbing with organic solvents, hot water, or hot water plus surfactant. The efficiency of removal was estimated either by visual examination of the amount remaining or by chemical analysis of the skin.
Hot water, hot soap solution and hot TEEPOL solution removed RM-17 from the skin and did not appear to enhance skin penetration.
Hot water and soap is recommended as an effective decontamination procedure.
Preliminary experiments indicated that RM-17 only slowly penetrated intact rabbit skin.
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