Registration Dossier

Administrative data

Endpoint:
short-term repeated dose toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: predates implementation of GLP and/or development of study guidelines, restrictions in reporting, acceptable with restrictions.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1965

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Two groups of Swiss mice were treated with daily doses of 250 and 500 mg/kg for 60 days. Mortality and toxic signs were recorded.
GLP compliance:
not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material: methylenedioxybenzene

Test animals

Species:
mouse
Strain:
Swiss

Administration / exposure

Route of administration:
oral: unspecified
Duration of treatment / exposure:
60 days
Frequency of treatment:
daily
Doses / concentrations
Remarks:
Doses / Concentrations:
250 and 500 mg/kg
Basis:
no data

Examinations

Observations and examinations performed and frequency:
Mortality and toxic signs were recorded.

Results and discussion

Results of examinations

Details on results:
At daily doses of 500 mg/kg methylenedioxybenzene the percentage mortality was 81%, 250 mg/kg/daily resulted in mortality of 73%. Methylenedioxybenzene produced both stimulation and depression.

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
At daily doses of 500 mg/kg and 250 mg/kg methylenedioxybenzene for 60 days, the mortality was 81% and 73%, respectively.
Executive summary:

Two groups of Swiss mice were treated with daily doses of 250 and 500 mg/kg for 60 days. Mortality and clinical signs were recorded. At daily doses of 500 mg/kg methylenedioxybenzene the percentage mortality was 81%, 250 mg/kg/daily resulted in a mortality of 73%. Methylenedioxybenzene produced both stimulation and depression.