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EC number: 219-145-8 | CAS number: 2372-82-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- Cited as Directive 92/69/EEC, A.6
- GLP compliance:
- yes
- Type of method:
- flask method
- Key result
- Water solubility:
- > 190 - < 460 g/L
- Temp.:
- 20 °C
- pH:
- >= 4 - <= 9
- Conclusions:
- Under the test conditions, the water solubility of the test substance in pH buffers of 4, 7 and 9 was determined to be >190 g/L at 20 ± 2ºC. The critical micelle concentration (CMC) was 51 mg/L.
- Executive summary:
A study was conducted to determine the water solubility of the test substance at 20ºC in pH buffers of 4, 7 and 9 according to EU Method A.6, in compliance with GLP. The water solubility was at least 190 g/kg (i.e., 190 g/L) at 20 ± 2ºC. At these concentrations, clear and slightly viscous solutions were obtained. Under these circumstances, it was not possible to maintain the initial buffer pH values. The pH in the three test buffers increased to above 11. At about 460 g/kg (i.e. 460 g/L) clear solid gels were obtained. These gels are not considered as solutions. The concentration of the test substance in these gels is therefore not reported as the solubility. Under the test conditions, the water solubility of the test substance in pH buffers of 4, 7 and 9 was determined to be >190 g/L at 20 ± 2ºC. The critical micelle concentration (CMC) was 51 mg/L (Geurts, 2002).
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- in house method based on EC method A6
- Principles of method if other than guideline:
- Mixtures of the test substance and water in the concentration range of 5 - 95% w/w were prepared and evaluated. Determination of the water solubility at pH 5, 7 and 9 was not viable because the test substance was extremely basic. The high concentrations of buffer solutions would be needed to conduct a studay and maintain the pH. This would further cause a problems with buffer salt solubility in water and test substance solubility in the buffer solutions.
- GLP compliance:
- yes
- Type of method:
- flask method
- Key result
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 822 g/L
- Temp.:
- 20 °C
- Remarks on result:
- other: gel formation at 45 -95 % (w/w)
- Details on results:
- Homogeneous gel formation when the proportion of the substance was in the 45 - 84% (w/w) at 20°C.
The highest test concentration was 95% w/w (822 g/L) and was miscible with water as a free flowing homogeneous liquid (pH was not measured but it was extremely basic). - Conclusions:
- Under the study conditions, within the concentration range of 45-95% w/w the test substance was miscible but not soluble in water forming a free flowing homogeneous liquid.
- Executive summary:
A study was conducted to determine the solubility of the test substance in water using a flask method. The tested concentrations were in the range of 45-95 % w/w, with 95% equal to the highest tested concentration of 822 g/L. The study temperature was 20°C and the pH was strongly basic. Determination of the water solubility at lower pH values up to 9 was not viable due to the basic nature of the substance. Under the study conditions, within the range of concentrations of 45-95% w/w, the test substance was miscible but not soluble in water forming a free flowing homogeneous liquid (Flack, 1996).
Referenceopen allclose all
Description of key information
Determination of the water solubility according to:
- EU Method A.6 (Geurts, 2002)
- Flask method (Flack, 1996)
Key value for chemical safety assessment
- Water solubility:
- 190 g/L
- at the temperature of:
- 20 °C
Additional information
- >190 g/L at 20 ± 2ºC (Geurts, 2002)
- the test substance was miscible but not soluble in water forming a free flowing homogeneous liquid (Flack, 1996)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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